Chiral Cyclometalated Oxazoline Gold(III) Complex-Catalyzed Asymmetric Carboalkoxylation of Alkynes

被引：34

作者：

Jiang, Jia-Jun ^{[1
]}

Cui, Jian-Fang ^{[1
,2
]}

Yang, Bin ^{[1
]}

Ning, Yulu ^{[1
]}

Lai, Nathanael Chun-Him ^{[1
]}

Wong, Man-Kin ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chem Biol & Drug Discovery, Hung Hom, Hong Kong, Peoples R China

[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 16期

关键词：

GOLD CATALYSIS; SILVER;

D O I：

10.1021/acs.orglett.9b02171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric catalysis by using novel chiral O,O'-chelated 4,4'-biphenol cyclometalated oxazoline gold(III) complexes has been developed. A high yield (<= 89%) and a high enantioselectivity (<= 90% ee) were achieved in asymmetric carboalkoxylation of alkynes. Enantioselectivity could be significantly improved from 19% to 90% ee by increasing the steric size of the substituent on the chiral oxazoline ligand. Catalytically active Au-III species and the origin of chiral induction are proposed.

引用

收藏

页码：6289 / 6294

页数：6

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