The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders

被引：121

作者：

Jo-Watanabe, Airi ^{[1
]}

Okuno, Toshiaki ^{[1
]}

Yokomizo, Takehiko ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Biochem, Tokyo 1138421, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 14期

关键词：

leukotriene; LTB4; BLT1; cysteinyl leukotriene; allergic disease; asthma; EXACERBATED RESPIRATORY-DISEASE; PROTEIN-COUPLED RECEPTOR; B-4; RECEPTOR; ATOPIC-DERMATITIS; CYSTEINYL LEUKOTRIENES; NEUTROPHILIC INFLAMMATION; LIPID MEDIATORS; MOUSE MODEL; PHARMACOLOGICAL CHARACTERIZATION; AIRWAY INFLAMMATION;

D O I：

10.3390/ijms20143580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications.

引用

页数：21

共 187 条

[1] Characterization of Mast Cell Activation Syndrome [J].

Afrin, Lawrence B. ;

Self, Sally ;

Menk, Jeremiah ;

Lazarchick, John .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2017, 353 (03) :207-215

[2] Involvement of leukotriene B4 in itching in a mouse model of ocular allergy [J].

Andoh, Tsugunobu ;

Sakai, Kazunari ;

Urashima, Masahisa ;

Kitazawa, Kayo ;

Honma, Azusa ;

Kuraishi, Yasushi .

EXPERIMENTAL EYE RESEARCH, 2012, 98 :97-103

[3] Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1 [J].

Arita, M ;

Bianchini, F ;

Aliberti, J ;

Sher, A ;

Chiang, N ;

Hong, S ;

Yang, R ;

Petasis, NA ;

Serhan, CN .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (05) :713-722

[4] ENHANCED GENERATION OF LEUKOTRIENE-B4 BY NEUTROPHILS STIMULATED BY UNOPSONIZED ZYMOSAN AND BY CALCIUM IONOPHORE AFTER EXERCISE-INDUCED ASTHMA [J].

ARM, JP ;

HORTON, CE ;

HOUSE, F ;

CLARK, TJH ;

SPUR, BW ;

LEE, TH .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (01) :47-53

[5] Leukotriene-E4 in human urine: Comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay [J].

Armstrong, Michael ;

Liu, Andrew H. ;

Harbeck, Ronald ;

Reisdorph, Rick ;

Rabinovitch, Nathan ;

Reisdorph, Nichole .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (27) :3169-3174

[6] Effects of leukotriene B4 receptor antagonist, LY293111Na, on antigen-induced bronchial hyperresponsiveness and leukocyte infiltration in sensitized guinea pigs [J].

Asanuma, F ;

Kuwabara, K ;

Arimura, A ;

Furue, Y ;

Fleisch, JH ;

Hori, Y .

INFLAMMATION RESEARCH, 2001, 50 (03) :136-141

[7] Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7 [J].

Back, Magnus ;

Powell, William S. ;

Dahlen, Sven-Erik ;

Drazen, Jeffrey M. ;

Evans, Jilly F. ;

Serhan, Charles N. ;

Shimizu, Takao ;

Yokomizo, Takehiko ;

Rovati, G. Enrico .

BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (15) :3551-3574

[8] Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99 [J].

Bankova, Lora G. ;

Lai, Juying ;

Yoshimoto, Eri ;

Boyce, Joshua A. ;

Austen, K. Frank ;

Kanaoka, Yoshihide ;

Barrett, Nora A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (22) :6242-6247

[9] Emerging Therapeutics for Ocular Surface Disease [J].

Bielory, Leonard ;

Schoenberg, Dovid .

CURRENT ALLERGY AND ASTHMA REPORTS, 2019, 19 (03)

[10] Exercise Increases Exhaled Breath Condensate Cysteinyl Leukotriene Concentration in Asthmatic Patients [J].

Bikov, Andras ;

Gajdocsi, Reka ;

Huszar, Eva ;

Szili, Balazs ;

Lazar, Zsofia ;

Antus, Balazs ;

Losonczy, Gyoergy ;

Horvath, Ildiko .

JOURNAL OF ASTHMA, 2010, 47 (09) :1057-1062

← 1 2 3 4 5 6 7 8 9 10 →