Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion

被引：25
|
作者：
Lai, Chun-Ming [1 ,2 ,3 ,5 ]
Lin, Kun-Yang [1 ,2 ,3 ,5 ]
Kao, Shih-Han [5 ]
Chen, Yi-Ning [6 ]
Huang, Fu [7 ]
Hsu, Hwei-Jan [1 ,2 ,4 ,5 ]
机构：
[1] Acad Sinica, Taiwan Int Grad Program, Mol & Biol Agr Sci Program, Taipei 11529, Taiwan
[2] Natl Chung Hsing Univ, Taipei 11529, Taiwan
[3] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 40227, Taiwan
[4] Natl Chung Hsing Univ, Biotechnol Ctr, Taichung 40227, Taiwan
[5] Acad Sinica, Inst Cellular & Organism Biol, Taipei 11529, Taiwan
[6] Acad Sinica, Inst Mol & Cell Biol, Taipei 11529, Taiwan
[7] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan
来源：
JOURNAL OF CELL BIOLOGY | 2017年 / 216卷 / 05期
关键词：
FACTOR TRAFFIC JAM; CUBITUS INTERRUPTUS; DROSOPHILA OVARY; MECHANISMS; GENE; IDENTIFICATION; SPECIFICATION; MORPHOGENESIS; TRANSCRIPTION; HOMEOSTASIS;
D O I：
10.1083/jcb.201610063
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity for somatic gonadal precursors to specify stromal intermingled cells, which contributes to both germline stem cell maintenance and differentiation niches in the adult. We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammals) is a novel transcriptional target of Hh signaling to control cell-cell adhesion by negative regulation of E-cadherin expression. Our results demonstrate the role of Hh signaling in niche establishment by segregating somatic cell lineages for differentiation.
引用
收藏
页码：1439 / 1453
页数：15
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