Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology

被引：95

作者：

Liu, XD ^{[1
]}

Xue, WM ^{[1
]}

Liu, Q ^{[1
]}

Yu, WT ^{[1
]}

Fu, YL ^{[1
]}

Xiong, X ^{[1
]}

Ma, XJ ^{[1
]}

Yuan, Q ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2004年 / 56卷 / 04期

基金：

中国国家自然科学基金;

关键词：

swelling behaviour; alginate-chitosan microcapsule; external gelation; internal gelation;

D O I：

10.1016/j.carbpol.2004.03.011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (S-w) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low S-w. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that S-w of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：459 / 464

页数：6

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