Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology

被引：25

作者：

Dogra, Samriti ^{[1
]}

Kaskel, Frederick ^{[2
]}

机构：

[1] Connecticut Childrens Med Ctr, Div Pediat Nephrol, Dept Pediat, 282 Washington St, Hartford, CT 06095 USA

[2] Childrens Hosp, Albert Einstein Coll Med, Montefiore Med Ctr, Div Pediat Nephrol,Dept Pediat, Bronx, NY USA

来源：

PEDIATRIC NEPHROLOGY | 2017年 / 32卷 / 06期

关键词：

Steroid-resistant nephrotic syndrome; Focal segmental glomerulosclerosis; Minimal change disease; Genetic testing; Glomerular filtration barrier; Podocyte; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; PLASMINOGEN-ACTIVATOR RECEPTOR; CLINICAL-TRIAL; GLOMERULAR-PERMEABILITY; UROKINASE RECEPTOR; IDIOPATHIC FSGS; MUTATIONS; SERUM; PROTEINURIA; RITUXIMAB;

D O I：

10.1007/s00467-016-3459-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

引用

页码：965 / 974

页数：10

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