Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment

被引：4

作者：

Feng, Wei-Hsiang ^{[1
]}

Chen, Ying-Yi ^{[1
]}

Kuo, Yen-Shou ^{[1
]}

Lin, Kuan-Hsun ^{[1
]}

Tsai, Yuan-Ming ^{[1
]}

Wu, Ti-Hui ^{[1
]}

Huang, Hsu-Kai ^{[1
]}

Huang, Tsai-Wang ^{[1
]}

机构：

[1] Triserv Gen Hosp, Div Thorac Surg, Dept Surg, Natl Def Med Ctr, 325,Sec 2,Chenggong Rd, Taipei 114, Taiwan

来源：

BMC CANCER | 2022年 / 22卷 / 01期

关键词：

Esophageal squamous cell carcinoma; (18)FDG-PET; CT; SUVmax; Pathological complete response; Prognostic factors; CHEMORADIOTHERAPY PLUS SURGERY; NEOADJUVANT CHEMORADIOTHERAPY; PREOPERATIVE CHEMORADIOTHERAPY; RECURRENCE PATTERN; COMPLETE RESPONSE; CANCER; CHEMORADIATION;

D O I：

10.1186/s12885-022-09852-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose This study aimed to determine the pathological complete response (pCR), overall survival (OS), and disease-free survival (DFS) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) using post-neoadjuvant chemoradiotherapy (nCRT) F-18-fluorodeoxyglucose ((18)FDG). Methods This is a retrospective study of patients with locally advanced ESCC receiving nCRT and then esophagectomy between January 2011 and December 2018 in the Tri-Service General Hospital, Taipei, Taiwan. A total of 50 patients were enrolled in the study. Survival analysis was performed using the Kaplan-Meier method and Cox proportional hazards model. Univariate and multivariate analysis were used to determine the independent prognostic factors. Results Fifty patients were enrolled in the study, and 18 had pathological complete response. Post-nCRT SUVmax >= 3 is a poor prognostic factor associated with overall survival (HR: 3.665, P = 0.013) and disease-free survival (HR: 3.417, P = 0.011). Poor prognosis was found in the non-pCR plus post-nCRT SUVmax >= 3 group compared with pCR plus post-nCRT SUVmax < 3 group. Conclusions SUVmax >= 3 is a poor prognostic factor in esophageal squamous cell carcinoma after trimodality treatment, even in patients having pathological complete response.

引用

页数：8

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