Open access chemical and clinical probes to support drug discovery

被引：79
作者：
Edwards, Aled M. [1 ]
Bountra, Chas [2 ]
Kerr, David J. [3 ]
Willson, Timothy M. [4 ]
机构：
[1] Univ Toronto, Struct Genom Consortium, Toronto, ON, Canada
[2] Univ Oxford, Struct Genom Consortium, Oxford, England
[3] Qatar Fdn, Sidra Med & Res Ctr, Doha, Qatar
[4] GlaxoSmithKline, Discovery Med Chem, Res Triangle Pk, NC USA
来源：
NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 07期
基金：
加拿大健康研究院; 英国惠康基金;
关键词：
ORPHAN NUCLEAR RECEPTORS; SUBSTANCE-P; SYNOVIAL-FLUID; PAIN; BRADYKININ; INHIBITORS; ARTHRITIS; GENOMICS;
D O I：
10.1038/nchembio0709-436
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drug discovery resources in academia and industry are not used efficiently, to the detriment of industry and society. Duplication could be reduced, and productivity could be increased, by performing basic biology and clinical proofs of concept within open access industry-academia partnerships. Chemical biologists could play a central role in this effort.
引用
收藏
页码：436 / 440
页数：5
相关论文
共 26 条
  • [1] Development of farnesyl transferase inhibitors: A review
    Appels, NMGM
    Beijnen, JH
    Schellens, JHM
    [J]. ONCOLOGIST, 2005, 10 (08) : 565 - 578
  • [2] Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P
    Babenko, V
    Graven-Nielsen, T
    Svensson, P
    Drewes, AM
    Jensen, TS
    Arendt-Nielsen, L
    [J]. EUROPEAN JOURNAL OF PAIN-LONDON, 1999, 3 (02): : 93 - 102
  • [3] Boyce S, 2000, PROG PAIN RES MANAG, V16, P313
  • [4] Nuclear receptors and lipid physiology: Opening the X-files
    Chawla, A
    Repa, JJ
    Evans, RM
    Mangelsdorf, DJ
    [J]. SCIENCE, 2001, 294 (5548) : 1866 - 1870
  • [5] Large-Scale Structural Biology of the Human Proteome
    Edwards, Aled
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 : 541 - 568
  • [6] MMPs as therapeutic targets - Still a viable option?
    Fingleton, Barbara
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2008, 19 (01) : 61 - 68
  • [7] Garnier JP, 2008, HARVARD BUS REV, V86, P68
  • [8] Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists
    Gharat, Laxmikant A.
    Szallasi, Arpad
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2008, 18 (02) : 159 - 209
  • [9] Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway
    Gunthorpe, Martin J.
    Chizh, Boris A.
    [J]. DRUG DISCOVERY TODAY, 2009, 14 (1-2) : 56 - 67
  • [10] An index to quantify an individual's scientific research output
    Hirsch, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (46) : 16569 - 16572
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