The X11/Mint family of adaptor proteins

被引：72

作者：

Rogelj, Boris

Mitchell, Jacqueline C.

Miller, Christopher C. J.

McLoughlin, Declan M.

机构：

[1] Kings Coll London, MRC, Ctr Neurodegenerat Res, Sect Old Age Psychiat,Inst Psychiat, London SE5 8AF, England

[2] Kings Coll London, MRC, Ctr Neurodegenerat Res, Dept Neurosci,Inst Psychiat, London SE5 8AF, England

来源：

BRAIN RESEARCH REVIEWS | 2006年 / 52卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

X11; Mint; LIN-10; Alzheimer's disease; neurodegeneration;

D O I：

10.1016/j.brainresrev.2006.04.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The X11 protein family are multidomain proteins composed of a conserved PTB domain and two C-terminal PDZ domains. They are involved in formation of multiprotein complexes and two of the family members, X11 alpha and X11 beta, are expressed primarily in neurones. Not much is known about the principal function of X11s, but through interactions with other neuronal proteins, they are believed to be involved in regulating neuronal signaling, trafficking and plasticity. Furthermore, they have been shown to modulate processing of APT and accumulation of A, making them potential therapeutic targets for Alzheimer's disease. This article reviews the known interactions of the different X11s and their involvement in Alzheimer's disease. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：305 / 315

页数：11

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