FXR, a multipurpose nuclear receptor

被引:297
作者
Lee, Florence Y.
Lee, Hans
Hubbert, Melissa L.
Edwards, Peter A. [1 ]
Zhang, Yanqiao
机构
[1] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/j.tibs.2006.08.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The farnesoid X receptor (FXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamilly. In the past six years, remarkable inroads have been made into determining the functional importance of FXR. This receptor has been shown to have crucial roles in controlling bile acid homeostasis, lipoprotein and glucose metabolism, hepatic regeneration, intestinal bacterial growth and the response to hepatotoxins. Thus, the development of FXR agonists might prove useful for the treatment of diabetes, cholesterol gallstones, and hepatic and intestinal toxicity.
引用
收藏
页码:572 / 580
页数:9
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