A Novel Risk Haplotype of ALOX5AP Gene is Associated with Ischemic Stroke in Chinese Han Population

被引：10

作者：

Yang, Dongzhi ^{[1
]}

He, Ying ^{[2
]}

Li, Manyu ^{[2
]}

Shi, Congcong ^{[2
]}

Song, Guoying ^{[2
]}

Wang, Qing ^{[2
]}

Fan, Yujia ^{[2
]}

Feng, Qingchuan ^{[2
]}

Zheng, Hong ^{[2
]}

机构：

[1] Zhengzhou Univ, Dept Bioengn, Zhengzhou 450052, Peoples R China

[2] Zhengzhou Univ, Dept Med Genet, Basic Med Coll, Zhengzhou 450052, Peoples R China

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2014年 / 53卷 / 03期

关键词：

ALOX5AP; Haplotype; Ischemic stroke; Polymorphism; ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN; MYOCARDIAL-INFARCTION; ACTIVATING PROTEIN; PHOSPHODIESTERASE; 4D; POLYMORPHISM; VARIANTS; METAANALYSIS; DISEASE;

D O I：

10.1007/s12031-013-0147-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have implicated that two at-risk haplotypes (HapA and HapB) of gene-encoding 5-lipoxygenase-activating protein (ALOX5AP) were significantly associated with stroke. The aim of this study was to explore the association between haplotypes of ALOX5AP gene and risk for ischemic stroke (IS) in Chinese Han population. A total of 492 patients with IS and 490 matched control subjects were recruited. Six ALOX5AP SNPs (SG13S377, SG13S114, SG13S41, SG13S89, SG13S32 and SG13S35) were genotyped by SNaPshot minisequence technique. A common genetic variant SG13S114/AA in the ALOX5AP gene was associated with IS in this Chinese cohort (OR = 2.514, 95 % CI = 1.667 similar to 3.790). HapA (TGA) and HapB (AAAG) had no significant difference in the patients (36.3 and 18.5 %, respectively) and controls (37.6 and 16.3 %, respectively) (P = 0.631 and P = 0.375, respectively). But, the frequency of Hap (GAAG) was significantly higher in the patients than that in the controls after Bonferroni's adjustment (P = 0.006). To conclude, SG13S114/AA of the ALOX5AP gene was associated with an increased risk for IS. A novel risk haplotype, Hap (GAAG) was a genetic risk factor for IS in this Chinese population.

引用

页码：493 / 499

页数：7

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