Biochips on CMOS:: an active matrix address array for DNA analysis

This paper reports a new development using a fully silicon active substrate and DNA probe electro-immobilisation. The DNA chip described is using CMOS 0.8 mu m technology and an integrated multiplexer to address successively the electrode on which a specific DNA probe will be deposited. This approach is well adapted for low to medium range number of probes (50-1000) device. Applications targeted by this kind of device are wide, from specific kit of diagnosis to cancerology and agronomy. The final demonstrator is a 128 DNA probe chip which is used for the analysis of genes involved in Oncology. (C) 1999 Elsevier Science S.A. All rights reserved.