Biochips on CMOS:: an active matrix address array for DNA analysis

被引：33

作者：

Caillat, P

David, D

Belleville, M

Clerc, F

Massit, C

Revol-Cavalier, F

Peltié, P

Livache, T

Bidan, G

Roget, A

Crapez, E

机构：

[1] CEA, LETI France, Serv Integrat Assemblage, Dept Microtechnol, F-38054 Grenoble 9, France

[2] Cisbio Int, F-30203 Bagnols, Ceze, France

[3] CEA, DRF, MC France, F-38054 Grenoble 9, France

[4] CRLC France, F-34298 Montpellier 5, France

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 1999年 / 61卷 / 1-3期

关键词：

DNA chip; active microelectrode array; oligonucleotide;

D O I：

10.1016/S0925-4005(99)00287-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper reports a new development using a fully silicon active substrate and DNA probe electro-immobilisation. The DNA chip described is using CMOS 0.8 mu m technology and an integrated multiplexer to address successively the electrode on which a specific DNA probe will be deposited. This approach is well adapted for low to medium range number of probes (50-1000) device. Applications targeted by this kind of device are wide, from specific kit of diagnosis to cancerology and agronomy. The final demonstrator is a 128 DNA probe chip which is used for the analysis of genes involved in Oncology. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：154 / 162

页数：9

共 12 条

[1] High-density oligonucleotide arrays [J].