Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses

被引：12
|
作者：
Nico, B
Mangieri, D
Corsi, P
De Giorgis, M
Vacca, A
Roncali, L
Ribatti, D
机构：
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy
[2] Univ Bari, Sch Med, Dept Physiol & Pharmacol, Bari, Italy
[3] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Bari, Italy
来源：
BRAIN RESEARCH | 2004年 / 1013卷 / 02期
关键词：
angiogenesis; angiopoietin-2; choroid plexus; vascular endothelial growth factor-A;
D O I：
10.1016/j.brainres.2004.04.016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, for the first time, we investigated about the localization of VEGF-A, VEGFR-2 and Ang-2 in the choroid plexuses of the adult mouse by Western blot and immunohistochemistry. Results showed that VEGF-A stained epithelial cells, while anti-VEGFR-2 and -Ang-2 antibodies stained endothelial cells. These data suggest that Ang-2, converting blood vessels into a more plastic and immature phenotype, would provide more accessibility of VEGF-A to endothelial cells. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：256 / 259
页数：4
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