Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity

被引：18
作者：
Braca, A
Armenise, A
Morelli, L
Mendez, J
Mi, QW
Chai, HB
Chai, HB
Swanson, SM
Kinghorn, AD
Kinghorn, AD
De Tommasi, N
机构：
[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy
[2] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56100 Pisa, Italy
[3] Cent Univ Venezuela, Escuela Quim, Caracas, Venezuela
[4] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60680 USA
来源：
PLANTA MEDICA | 2004年 / 70卷 / 06期
关键词：
Parinari sprucei; chrysobalanaceae; leaves; kaurane diterpenes; cytotoxicity; hollow fiber test;
D O I：
10.1055/s-2004-827155
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Twenty-three kaurane-type diterpenes 1-23, including twenty new natural products 1-20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED50 values in the range of 10-20 mug/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used.
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收藏
页码：540 / 550
页数：11
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