Exosomes in immunoregulation of chronic lung diseases

被引：78
作者：
Hough, K. P. [1 ]
Chanda, D. [1 ]
Duncan, S. R. [1 ]
Thannickal, V. J. [1 ]
Deshane, J. S. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, 1900 Univ Blvd,THT 433A, Birmingham, AL 35294 USA
来源：
ALLERGY | 2017年 / 72卷 / 04期
关键词：
chronic lung diseases; exosomes; extracellular vesicles; immunoregulation; inflammation; CELL-DERIVED EXOSOMES; DENDRITIC CELLS; T-CELLS; EXTRACELLULAR VESICLES; ANTIGEN PRESENTATION; EPITHELIAL-CELLS; CLASS-II; BRONCHOALVEOLAR LAVAGE; MULTIVESICULAR BODY; PEPTIDE COMPLEXES;
D O I：
10.1111/all.13086
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Exosomes are nano-sized, membrane-bound vesicles released from cells that transport cargo including DNA, RNA, and proteins, between cells as a form of intercellular communication. In addition to their role in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregulation that can modulate antigen presentation, immune activation, suppression, and surveillance. This article summarizes how these multifaceted functions of exosomes may promote development and/or progression of chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. The potential of exosomes as a novel therapeutic is also discussed.
引用
收藏
页码：534 / 544
页数：11
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