Scalable, efficient and rapid chemical synthesis of L-Fructose with high purity

被引：0

作者：

Li, Jihui ^{[1
]}

Song, Xinjing ^{[1
]}

Wu, Tianxiao ^{[1
]}

Zhao, Liyu ^{[1
]}

Qin, Qiaohua ^{[1
]}

Cheng, Maosheng ^{[1
]}

Liu, Yang ^{[1
]}

Zhao, Dongmei ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2019年 / 480卷

关键词：

L-fructose; Scalable synthesis; Good yield; High purity; Short time period; ASYMMETRIC EPOXIDATION; PRACTICAL SYNTHESIS; PHOSPHATE; SORBOSE;

D O I：

10.1016/j.carres.2019.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An improved process for chemical synthesis of L-fructose with high purity in large scale from readily available L-sorbose is described. In general, this synthetic scheme is characterized by inexpensive and easily available starting materials, simple and safe experimental procedures, short time period, low environmental impact, and great potential for scaling up. The scale-up experiment (100 g) was carried out to provide 42.7 g of L-fructose with high HPLC purity of 99.65% in total yield of 50.2%. Consequently, the described improvements would be helpful for those who may wish to use L-fructose and promoting the further evaluation of applications of L-fructose.

引用

页码：67 / 72

页数：6

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