Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues

被引：112
作者：
Fleischer, Sharon [1 ,2 ]
Shevach, Michal [1 ,2 ]
Feiner, Ron [1 ,2 ]
Dvir, Tal [1 ,2 ,3 ]
机构：
[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, Lab Tissue Engn & Regenerat Med, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel
[3] Tel Aviv Univ, Fac Engn, Dept Mat Sci & Engn, IL-69978 Tel Aviv, Israel
来源：
NANOSCALE | 2014年 / 6卷 / 16期
关键词：
STEM-CELLS; HEART; MUSCLE; PATCH;
D O I：
10.1039/c4nr00300d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.
引用
收藏
页码：9410 / 9414
页数：5
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