Greener synthesis of spirooxindole in deep eutectic solvent

被引：96

作者：

Azizi, Najmedin ^{[1
]}

Dezfooli, Sahar ^{[2
]}

Hashemi, Mohammad Mahmoudi ^{[3
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran

[2] Islamic Azad Univ, Sci & Res Branch, Young Researchers & Elites Club, Tehran, Iran

[3] Islamic Azad Univ, Dept Chem, Sci & Res Branch, Tehran, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2014年 / 194卷

关键词：

Acenaphthoquinone; Cumarin; Green chemistry; Spirooxindole; Ionic liquid; lsatin; EFFICIENT SYNTHESIS; IONIC LIQUIDS; POTENT;

D O I：

10.1016/j.molliq.2014.01.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple and efficient synthesis of spirooxindole derivatives by one-pot, three-component reaction of isatins, malononitrile and different nucleophiles under catalyst-free condition in deep eutectic solvent is reported. A series of biological importance, spirooxindole derivatives were synthesized via a multicomponent reaction of isatin, or acenaphthoquinone, and malononitrile or cyanoacetic ester with 1,3-dicarbonyl compounds, naphtol and 4-hydroxycumarin in biodegradable choline chloride based deep eutectic solvent in good yields (50-95%). This green procedure has the advantages of higher yields, shorter reaction times, environmental friendliness, and easy work-up.(c) 2014 Elsevier B.V. All rights reserved.

引用

页码：62 / 67

页数：6

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