Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area

被引:29
作者
Bushell, Michael [1 ]
Beauchemin, Suzanne [2 ]
Kunc, Filip [1 ]
Gardner, David [3 ]
Ovens, Jeffrey [3 ]
Toll, Floyd [4 ]
Kennedy, David [1 ]
Nguyen, Kathy [5 ]
Vladisavljevic, Djordje [5 ]
Rasmussen, Pat E. [2 ]
Johnston, Linda J. [1 ]
机构
[1] Natl Res Council Canada, Metrol Res Ctr, Ottawa, ON K1A 0R6, Canada
[2] Hlth Canada, Environm Hlth Res Sci Bur, 251 Sir Banting Driveway, Frederick, ON K1A 0K9, Canada
[3] Univ Ottawa, Xray Core Facil, Stem Complex,150 Louis Pasteur, Ottawa, ON K1N 6N5, Canada
[4] Natl Res Council Canada, Energy Min & Environm Res Ctr, Ottawa, ON K1A 0R6, Canada
[5] Hlth Canada, New Subst Assessment Control Bur, 269 Laurier Ave West, Ottawa, ON K1A 0K9, Canada
关键词
metal oxide nanomaterials; X-ray diffraction; transmission electron microscopy; specific surface area; crystalline phase; RAY-DIFFRACTION METHODS; METROLOGICAL CHARACTERIZATION; MANUFACTURED NANOMATERIALS; PHYSICOCHEMICAL PROPERTIES; NANOPARTICLES; DISTRIBUTIONS; DISSOLUTION; STABILITY; RELEVANT; HEALTH;
D O I
10.3390/nano10091812
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Physical chemical characterization of nanomaterials is critical to assessing quality control during production, evaluating the impact of material properties on human health and the environment, and developing regulatory frameworks for their use. We have investigated a set of 29 nanomaterials from four metal oxide families (aluminum, copper, titanium and zinc) with a focus on the measurands that are important for the basic characterization of dry nanomaterials and the determination of the dose metrics for nanotoxicology. These include crystalline phase and crystallite size, measured by powder X-ray diffraction, particle shape and size distributions from transmission electron microscopy, and specific surface area, measured by gas adsorption. The results are compared to the nominal data provided by the manufacturer, where available. While the crystalline phase data are generally reliable, data on minor components that may impact toxicity is often lacking. The crystal and particle size data highlight the issues in obtaining size measurements of materials with broad size distributions and significant levels of aggregation, and indicate that reliance on nominal values provided by the manufacturer is frequently inadequate for toxicological studies aimed at identifying differences between nanoforms. The data will be used for the development of models and strategies for grouping and read-across to support regulatory human health and environmental assessments of metal oxide nanomaterials.
引用
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页码:1 / 19
页数:19
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