Are there differences in basal thrombophilias and C-reactive protein between women with or without PCOS?

被引:9
作者
Sanchez-Ferrer, Maria L. [1 ,2 ]
Prieto-Sanchez, Maria T. [1 ,2 ]
Corbalan-Biyang, Shiana [1 ]
Mendiola, Jaime [2 ,3 ,4 ]
Adoamnei, Evdochia [2 ,3 ]
Hernandez-Penalver, Ana, I [1 ]
Carmona-Barnosi, Ana [1 ]
Salido-Fierrez, Eduardo J. [2 ,5 ]
Torres-Cantero, Alberto M. [2 ,3 ,4 ,6 ]
机构
[1] Virgen de la Arrixaca Univ Clin Hosp, Dept Obstet & Gynecol, El Palmar Murcia 30120, Spain
[2] IMIB Arrixaca, Inst Biomed Res Murcia, El Palmar Murcia 30120, Spain
[3] Univ Murcia, Dept Publ Hlth Sci, Div Prevent Med & Publ Hlth, Sch Med, Espinardo 30100, Spain
[4] Inst Salud Carlos III, Consortium Biomed Res Epidemiol & Publ Hlth, CIBER Epidemiologfa & Salud Publ, CIBERESP, Madrid 28029, Spain
[5] Virgen de la Arrixaca Univ Clin Hosp, Dept Hematol & Hemotherapy, El Palmar Murcia 30120, Spain
[6] Virgen de la Arrixaca Univ Clin Hosp, Dept Prevent Med, El Palmar Murcia 30120, Spain
关键词
Basal thrombophilia; C-reactive protein; Hormones; PCOS subtypes; Polycystic ovary syndrome; POLYCYSTIC-OVARY-SYNDROME; ACTIVATABLE FIBRINOLYSIS INHIBITOR; HORMONE-BINDING GLOBULIN; INDEPENDENT RISK-FACTOR; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ANDROGEN LEVELS; BODY-MASS; PREGNANCY; HYPERANDROGENEMIA;
D O I
10.1016/j.rbmo.2019.01.013
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Research question: Polycystic ovary syndrome (PCOS) women have increased cardiovascular risks, although it is unclear whether the haemostatic system and coagulation contribute to that increased risk. Design: Women attending the Gynecology Unit of the 'Virgen de la Arrixaca' University Hospital (Murcia, Spain) for routine gynaecological examinations between September 2014 and May 2016 were assessed for PCOS using the Rotterdam criteria (hyperandrogenism [H], oligo/amenorrhoea [O] and polycystic ovarian morphology [POM]) and were classified into four phenotypic. In total, 126 cases were identified and 159 control women were selected. All women underwent physical and gynaecological examinations, and blood tests between the second and fifth day of the menstrual cycle. Differences in hormonal, basal thrombophilia and metabolic parameters, and C-reactive protein (CRP) between PCOS and controls were analysed. Results: After adjusting by BMI and age, PCOS women had higher LH (P < 0.001), testosterone (P < 0.001), free testosterone (P = 0.01) and anti-Mullerian hormone (P < 0.001) and lower FSH (P = 0.03) compared with controls, whereas sex hormone-binding globulin was no different. Cases showed significantly higher protein S, glucose, insulin and insulin resistance (HOMAIR) compared with controls (P < 0.05). There were no differences in protein C levels, antithrombin III, prothrombin time, homocysteine, D-dimer, factor V Leyden, prothrombin G20210A polymorphism or CRP. The H+O phenotype showed the poorest results for insulin and HOMA-IR (P = 0.04 and 0.05). Conclusions: The results suggest that there are no differences in the basal thrombophilias between women with and without PCOS. However, PCOS with H+O shows the poorest metabolic profile.
引用
收藏
页码:1018 / 1026
页数:9
相关论文
共 74 条
[1]  
Afifi L, 2017, Int J Womens Dermatol, V3, P37, DOI 10.1016/j.ijwd.2017.01.006
[2]   The plasminogen activator system in women with polycystic ovary syndrome [J].
Atiomo, WU ;
Bates, SA ;
Condon, JE ;
Shaw, S ;
West, JH ;
Prentice, AG .
FERTILITY AND STERILITY, 1998, 69 (02) :236-241
[3]   Raised plasminogen activator inhibitor-1 (PAI-1) is not an independent risk factor in the polycystic ovary syndrome (PCOS) [J].
Atiomo, WU ;
Fox, R ;
Condon, JE ;
Shaw, S ;
Friend, JJ ;
Prentice, AG ;
Wilkin, TJ .
CLINICAL ENDOCRINOLOGY, 2000, 52 (04) :487-492
[4]   Are women with polycystic ovary syndrome resistant to activated protein C? [J].
Atiomo, WU ;
Condon, J ;
Adekanmi, OA ;
Friend, J ;
Wilkin, TJ ;
Prentice, AG .
FERTILITY AND STERILITY, 2000, 74 (06) :1229-1232
[5]   Endogenous thrombin potential in polycystic ovary syndrome: the association to body mass index, insulin resistance, and inflammation [J].
Aziz, Mubeena ;
Sidelmann, Johannes J. ;
Wissing, Marie Louise Muff ;
Faber, Jens ;
Skouby, Sven O. .
GYNECOLOGICAL ENDOCRINOLOGY, 2015, 31 (09) :720-724
[6]   Polycystic ovary syndrome: cardiovascular risk factors according to specific phenotypes [J].
Aziz, Mubeena ;
Sidelmann, Johannes J. ;
Faber, Jens ;
Wissing, Marie-Louise. M. ;
Naver, Klara V. ;
Mikkelsen, Anne-Lis ;
Nilas, Lisbeth ;
Skouby, Sven O. .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2015, 94 (10) :1082-1089
[7]   The prevalence and features of the polycystic ovary syndrome in an unselected population [J].
Azziz, R ;
Woods, KS ;
Reyna, R ;
Key, TJ ;
Knochenhauer, ES ;
Yildiz, BO .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2745-2749
[8]   Polycystic Ovary Syndrome [J].
Azziz, Ricardo .
OBSTETRICS AND GYNECOLOGY, 2018, 132 (02) :321-336
[9]   Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome [J].
Barber, Thomas M. ;
Wass, John A. H. ;
McCarthy, Mark I. ;
Franks, Stephen .
CLINICAL ENDOCRINOLOGY, 2007, 66 (04) :513-517
[10]   The impact of hyperandrogenism in female obesity and cardiometabolic diseases associated with polycystic ovary syndrome [J].
Barber, Thomas M. ;
Vojtechova, Petra ;
Franks, Stephen .
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2013, 15 (03) :91-103