Apoptosis and Cancer: Force Awakens, Phantom Menace, or Both?

被引：56

作者：

Cao, Kai ^{[1
,2
]}

Tait, Stephen W. G. ^{[1
,2
]}

机构：

[1] Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

[2] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 337 | 2018年 / 337卷

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; BH3 MIMETIC ABT-199; CELL-DEATH; BREAST-CANCER; TUMOR-CELLS; DNA-DAMAGE; ANTITUMOR-ACTIVITY; FAMILY PROTEINS; BLADDER-CANCER; LIVER-CANCER;

D O I：

10.1016/bs.ircmb.2017.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptotic cell death serves as an important tumor suppressor mechanism at multiple steps during cancer progression. Equally, engagement of apoptosis represents a potent therapeutic effector mechanism. Nevertheless, the role of apoptosis in cancer may be more complex than previously thought. Indeed, various studies have found that apoptosis signaling also has oncogenic potential. In this review, we discuss how apoptosis can promote cancer and how these effects might be targeted to optimize apoptosis-inducing anticancer therapy.

引用

页码：135 / 152

页数：18

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