The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

被引：42
作者：
la Cour, Jonas M. [1 ]
Hoj, Berit R. [1 ]
Mollerup, Jens [1 ]
Simon, Ronald [2 ]
Sauter, Guido [2 ]
Berchtold, Martin W. [1 ]
机构：
[1] Univ Copenhagen, Dept Mol Biol, Copenhagen Bioctr, DK-2200 Copenhagen N, Denmark
[2] Univ Med Ctr Hamburg Eppendorf, Dept Pathol, Hamburg, Germany
来源：
MOLECULAR ONCOLOGY | 2008年 / 1卷 / 04期
关键词：
Calcium binding proteins; Tissue microarray; Gene silencing; ALG-2;
D O I：
10.1016/j.molonc.2007.08.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：431 / 439
页数：9
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