Levetiracetam pharmacokinetics in neonates at birth

被引：18

作者：

Allegaert, K

Lewi, L

Naulaers, G

Lagae, L

机构：

[1] Univ Hosp Gasthuisberg, Neonatal Intens Care Unit, Div Women & Child, B-3000 Louvain, Belgium

[2] Univ Hosp Gasthuisberg, Dept Obstet & Gynaecol, Div Women & Child, B-3000 Louvain, Belgium

[3] Univ Hosp Gasthuisberg, Dept Paediat Neurol, Div Women & Child, B-3000 Louvain, Belgium

来源：

EPILEPSIA | 2006年 / 47卷 / 06期

关键词：

developmental pharmacology; levetira cetam; pharmacokinetics;

D O I：

10.1111/j.1528-1167.2006.00576.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Based on blood sampling in a formula-fed pair of twins, the estimated serum half-life of levetiracetam (LEV) at birth is 16-18 h.

引用

页码：1068 / 1069

页数：2

共 7 条

[1] The pharmacokinetics and interactions of new antiepileptic drugs - An overview [J].

Bialer, M .

THERAPEUTIC DRUG MONITORING, 2005, 27 (06) :722-726

[2] Levetiracetam concentrations in serum and in breast milk at birth and during lactation [J].

Johannessen, SI ;

Helde, G ;

Brodtkorb, E .

EPILEPSIA, 2005, 46 (05) :775-777

[3] Developmental pharmacology - Drug disposition, action, and therapy in infants and children [J].

Kearns, GL ;

Abdel-Rahman, SM ;

Alander, SW ;

Blowey, DL ;

Leeder, JS ;

Kauffman, RE .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (12) :1157-1167

[4] Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial [J].

Lagae, L ;

Buyse, G ;

Ceulemans, B .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2005, 14 (01) :66-71

[5] Clinical pharmacokinetics of levetiracetam [J].

Patsalos, PN .

CLINICAL PHARMACOKINETICS, 2004, 43 (11) :707-724

[6] Pharmacokinetic study of levetiracetam in children [J].

Pellock, JM ;

Glauser, TA ;

Bebin, EM ;

Fountain, NB ;

Ritter, FJ ;

Coupez, RM ;

Shields, WD .

EPILEPSIA, 2001, 42 (12) :1574-1579

[7] Pharmacokinetic variability of new antiepileptic drugs at different ages [J].

Perucca, E .

THERAPEUTIC DRUG MONITORING, 2005, 27 (06) :714-717

← 1 →