HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin

被引：1
|
作者：
Tzou, Ywh-Min [1 ,2 ,3 ]
Shin, Ronald [1 ,2 ]
Krishna, N. Rama [1 ,2 ]
机构：
[1] Univ Alabama Birmingham, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Comprehens Canc Ctr, Birmingham, AL 35294 USA
[3] Auburn Univ, Scott Ritchey Res Ctr, Coll Vet Med, Auburn, AL 36849 USA
来源：
NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 05期
基金：
美国国家卫生研究院;
关键词：
HIV-1; virus; calmodulin; capsid protein; N-terminal domain; ITC; NMR; CRYSTAL-STRUCTURE; BINDING DOMAIN; IDENTIFICATION; FLEXIBILITY; REGION; TYPE-1; VPR;
D O I：
10.1177/1934578X19849190
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The human immunodeficiency virus (HIV-1 virus) exploits several host factors for assembly, infection, and replication within the infected cells. In this work, we describe the evidence for an interaction of the N-terminal domain of the HIV-1 capsid protein with human calmodulin. The precise role of this interaction within the life cycle of the HIV-1 virus is yet to be defined. Potential roles for this interaction in the viral capsid uncoating are discussed.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors
    Mascarenhas, Anjali P.
    Musier-Forsyth, Karin
    FEBS JOURNAL, 2009, 276 (21) : 6118 - 6127
  • [2] Capsid-host interactions for HIV-1 ingress
    Jang, Sooin
    Engelman, Alan N.
    MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2023, 87 (04)
  • [3] A snapshot of HIV-1 capsid-host interactions
    Temple, Joshua
    Tripler, Therese N.
    Shen, Qi
    Xiong, Yong
    CURRENT RESEARCH IN STRUCTURAL BIOLOGY, 2020, 2 : 222 - 228
  • [4] The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor
    Ternois, F
    Sticht, J
    Duquerroy, S
    Kräusslich, HG
    Rey, FA
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (08) : 678 - 682
  • [5] The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor
    François Ternois
    Jana Sticht
    Stéphane Duquerroy
    Hans-Georg Kräusslich
    Félix A Rey
    Nature Structural & Molecular Biology, 2005, 12 : 678 - 682
  • [6] Backbone 15N relaxation analysis of the N-terminal domain of the HTLV-I capsid protein and comparison with the capsid protein of HIV-1
    Cornilescu, CC
    Bouamr, F
    Carter, C
    Tjandra, N
    PROTEIN SCIENCE, 2003, 12 (05) : 973 - 981
  • [7] Structure of the amino-terminal core domain of the HIV-1 capsid protein
    Gitti, RK
    Lee, BM
    Walker, J
    Summers, MF
    Yoo, S
    Sundquist, WI
    SCIENCE, 1996, 273 (5272) : 231 - 235
  • [8] Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein
    Gamble, TR
    Yoo, SH
    Vajdos, FF
    vonSchwedler, UK
    Worthylake, DK
    Wang, H
    McCutcheon, JP
    Sundquist, WI
    Hill, CP
    SCIENCE, 1997, 278 (5339) : 849 - 853
  • [9] Structure, Function, and Interactions of the HIV-1 Capsid Protein
    Rossi, Eric
    Meuser, Megan E.
    Cunanan, Camille J.
    Cocklin, Simon
    LIFE-BASEL, 2021, 11 (02): : 1 - 25
  • [10] Crystal structure of the N-terminal domain of HIV-1 capsid in complex with an assembly- inhibiting nanobody
    Castillo, Luis
    Helma, Jonas
    Guardado, Pablo
    Rothbauer, Ulrich
    Rey, Felix
    Leonhardt, Heirich
    Kraeusslich, Hans-Georg
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2011, 67 : C76 - C77
12345