Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome

被引：33

作者：

Zhao, Yanlin ^{[1
]}

Marple, Andrew H. ^{[1
]}

Ferguson, David J. P. ^{[2
]}

Bzik, David J. ^{[3
]}

Yap, George S. ^{[1
]}

机构：

[1] Rutgers State Univ, New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07101 USA

[2] Oxford Univ Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9D5, England

[3] Geisel Sch Med Dartmouth, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 17期

关键词：

virulence; Trojan horse; apicomplexa; phagocytes; HOST-CELL; PARASITE; ACIDIFICATION; VACUOLAR; VIRULENCE; GENOTYPE; IMMUNITY; FUSION; IL-12;

D O I：

10.1073/pnas.1316841111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Unlike most intracellular pathogens that gain access into host cells through endocytic pathways, Toxoplasma gondii initiates infection at the cell surface by active penetration through a moving junction and subsequent formation of a parasitophorous vacuole. Here, we describe a noncanonical pathway for T. gondii infection of macrophages, in which parasites are initially internalized through phagocytosis, and then actively invade from within a phagosomal compartment to form a parasitophorous vacuole. This phagosome to vacuole invasion (PTVI) pathway may represent an intermediary link between the endocytic and the penetrative routes for host cell entry by intracellular pathogens. The PTVI pathway is preferentially used by avirulent strains of T. gondii and confers an infectious advantage over virulent strains for macrophage tropism.

引用

页码：6437 / 6442

页数：6

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