A model for bidirectional traffic of cytoskeletal motors

被引:25
作者
Ebbinghaus, Maximilian [1 ]
Santen, Ludger [1 ]
机构
[1] Univ Saarland, D-66041 Saarbrucken, Germany
关键词
cellular automata; molecular motors (theory); ASYMMETRIC EXCLUSION PROCESSES; CYTOPLASMIC DYNEIN; TRANSPORT; PROCESSIVITY; MICROTUBULES; BREAKING;
D O I
10.1088/1742-5468/2009/03/P03030
中图分类号
O3 [力学];
学科分类号
08 ; 0801 ;
摘要
We introduce a stochastic lattice gas model including two particle species and two parallel lanes, one of which comprises exclusion interaction and directed motion while the other shows no exclusion interaction and unbiased diffusion, thus mimicking a microtubule. lament and the surrounding solution. At a high binding affinity to the. lament, jam-like situations dominate the system's behaviour. We approximated the fundamental process of position exchange of two particles. In the case of a many-particle system, we were able to identify one regime in which the system is rather homogeneous with only small accumulations of particles and another regime in which a significant fraction of all particles accumulate in the same cluster. Numerical data indicate that this cluster formation will occur at all densities for large system sizes. Coupling of several. laments leads to an increased cluster formation as compared to the uncoupled system, suggesting that efficient bidirectional transport on one-dimensional filaments relies on long-ranged interactions and track formation.
引用
收藏
页数:19
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共 40 条
[21]   Cell motility driven by actin polymerization [J].
Mogilner, A ;
Oster, G .
BIOPHYSICAL JOURNAL, 1996, 71 (06) :3030-3045
[22]   Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors [J].
Mueller, Melanie J. I. ;
Klumpp, Stefan ;
Lipowsky, Reinhard .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4609-4614
[23]   Intracellular transport of single-headed molecular motors KIF1A [J].
Nishinari, K ;
Okada, Y ;
Schadschneider, A ;
Chowdhury, D .
PHYSICAL REVIEW LETTERS, 2005, 95 (11)
[24]   A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules [J].
Nishiura, M ;
Kon, T ;
Shiroguchi, K ;
Ohkura, R ;
Shima, T ;
Toyoshima, YY ;
Sutoh, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (22) :22799-22802
[25]   Phase coexistence in driven one-dimensional transport [J].
Parmeggiani, A ;
Franosch, T ;
Frey, E .
PHYSICAL REVIEW LETTERS, 2003, 90 (08) :4
[26]   Spontaneous symmetry breaking in two-channel asymmetric exclusion processes with narrow entrances [J].
Pronina, Ekaterina ;
Kolomeisky, Anatoly B. .
JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL, 2007, 40 (10) :2275-2286
[27]   Single-molecule analysis of dynein processivity and stepping behavior [J].
Reck-Peterson, Samara L. ;
Yildiz, Ahmet ;
Carter, Andrew P. ;
Gennerich, Arne ;
Zhang, Nan ;
Vale, Ronald D. .
CELL, 2006, 126 (02) :335-348
[28]   Traffic jams induced by rare switching events in two-lane transport [J].
Reichenbach, Tobias ;
Frey, Erwin ;
Franosch, Thomas .
NEW JOURNAL OF PHYSICS, 2007, 9
[29]   Processive bidirectional motion of dynein-dynactin complexes in vitro [J].
Ross, Jennifer L. ;
Wallace, Karen ;
Shuman, Henry ;
Goldman, Yale E. ;
Holzbaur, Erika L. F. .
NATURE CELL BIOLOGY, 2006, 8 (06) :562-570
[30]   Molecular motors [J].
Schliwa, M ;
Woehlke, G .
NATURE, 2003, 422 (6933) :759-765