A model for bidirectional traffic of cytoskeletal motors

被引:25
作者
Ebbinghaus, Maximilian [1 ]
Santen, Ludger [1 ]
机构
[1] Univ Saarland, D-66041 Saarbrucken, Germany
关键词
cellular automata; molecular motors (theory); ASYMMETRIC EXCLUSION PROCESSES; CYTOPLASMIC DYNEIN; TRANSPORT; PROCESSIVITY; MICROTUBULES; BREAKING;
D O I
10.1088/1742-5468/2009/03/P03030
中图分类号
O3 [力学];
学科分类号
08 ; 0801 ;
摘要
We introduce a stochastic lattice gas model including two particle species and two parallel lanes, one of which comprises exclusion interaction and directed motion while the other shows no exclusion interaction and unbiased diffusion, thus mimicking a microtubule. lament and the surrounding solution. At a high binding affinity to the. lament, jam-like situations dominate the system's behaviour. We approximated the fundamental process of position exchange of two particles. In the case of a many-particle system, we were able to identify one regime in which the system is rather homogeneous with only small accumulations of particles and another regime in which a significant fraction of all particles accumulate in the same cluster. Numerical data indicate that this cluster formation will occur at all densities for large system sizes. Coupling of several. laments leads to an increased cluster formation as compared to the uncoupled system, suggesting that efficient bidirectional transport on one-dimensional filaments relies on long-ranged interactions and track formation.
引用
收藏
页数:19
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共 40 条
[11]   Criterion for phase separation in one-dimensional driven systems -: art. no. 035702 [J].
Kafri, Y ;
Levine, E ;
Mukamel, D ;
Schütz, GM ;
Török, J .
PHYSICAL REVIEW LETTERS, 2002, 89 (03) :357021-357024
[12]   Dynactin increases the processivity of the cytoplasmic dynein motor [J].
King, SJ ;
Schroer, TA .
NATURE CELL BIOLOGY, 2000, 2 (01) :20-24
[13]   Active diffusion of motor particles [J].
Klumpp, S ;
Lipowsky, R .
PHYSICAL REVIEW LETTERS, 2005, 95 (26)
[14]   Phase transitions in systems with two species of molecular motors [J].
Klumpp, S ;
Lipowsky, R .
EUROPHYSICS LETTERS, 2004, 66 (01) :90-96
[15]   Traffic of molecular motors through tube-like compartments [J].
Klumpp, S ;
Lipowsky, R .
JOURNAL OF STATISTICAL PHYSICS, 2003, 113 (1-2) :233-268
[16]   Long-range order in a quasi one-dimensional non-equilibrium three-state lattice gas [J].
Korniss, G ;
Schmittmann, B ;
Zia, RKP .
EUROPHYSICS LETTERS, 1999, 45 (04) :431-436
[17]   Competition of coarsening and shredding of clusters in a driven diffusive lattice gas [J].
Kunwar, Ambarish ;
Chowdhury, Debashish ;
Schadschneider, Andreas ;
Nishinari, Katsuhiro .
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, 2006,
[18]   Cooperative extraction of membrane nanotubes by molecular motors [J].
Leduc, C ;
Campàs, O ;
Zeldovich, KB ;
Roux, A ;
Jolimaitre, P ;
Bourel-Bonnet, L ;
Goud, B ;
Joanny, JF ;
Bassereau, P ;
Prost, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17096-17101
[19]   Random walks of cytoskeletal motors in open and closed compartments [J].
Lipowsky, R ;
Klumpp, S ;
Nieuwenhuizen, TM .
PHYSICAL REVIEW LETTERS, 2001, 87 (10) :art. no.-108101
[20]   Cytoplasmic dynein functions as a gear in response to load [J].
Mallik, R ;
Carter, BC ;
Lex, SA ;
King, SJ ;
Gross, SP .
NATURE, 2004, 427 (6975) :649-652