Signaling regulations of neuronal regenerative ability

被引：90

作者：

Lu, Yi ^{[1
,2
,3
]}

Belin, Stephane ^{[2
,3
]}

He, Zhigang ^{[2
,3
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurosurg, Boston, MA 02115 USA

[2] Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2014年 / 27卷

关键词：

PROMOTES AXONAL REGENERATION; LEUKEMIA INHIBITORY FACTOR; RETINAL GANGLION-CELLS; LEUCINE-ZIPPER KINASE; INJURED SPINAL-CORD; OPTIC-NERVE; GROWTH CONE; MAMMALIAN TARGET; IN-VIVO; PTEN;

D O I：

10.1016/j.conb.2014.03.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Different from physiological axon growth during development, a major limiting factor for successful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mammalian central nervous system (CNS). Recent studies identified several molecular pathways, including PTEN/mTOR, Jak/STAT, DLK/JNK, providing important probes in investigating the mechanisms by which the regenerative ability is regulated. This review will summarize these recent findings and speculate their implications.

引用

页码：135 / 142

页数：8

共 100 条

[61] No simpler than mammals: axon and dendrite regeneration in Drosophila [J].

Nawabi, Homaira ;

Zukor, Katherine ;

He, Zhigang .

GENES & DEVELOPMENT, 2012, 26 (14) :1509-1514

[62] Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways [J].

Nix, Paola ;

Hisamoto, Naoki ;

Matsumoto, Kunihiro ;

Bastiani, Michael .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (26) :10738-10743

[63] Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons [J].

Parikh, Pranav ;

Hao, Yuhan ;

Hosseinkhani, Mohsen ;

Patil, Shekhar B. ;

Huntley, George W. ;

Tessier-Lavigne, Marc ;

Zou, Hongyan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (19) :E99-E107

[64] Cytokine-induced SOCS expression is inhibited by cAMP analogue: Impact on regeneration in injured retina [J].

Park, Kevin K. ;

Hu, Ying ;

Muhling, Jillian ;

Pollett, Margaret A. ;

Dallimore, Elizabeth J. ;

Turnley, Ann M. ;

Cui, Qi ;

Harvey, Alan R. .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2009, 41 (03) :313-324

[65] The many faces of the SOCS box [J].

Piessevaux, Julie ;

Lavens, Delphine ;

Peelman, Frank ;

Tavernier, Jan .

CYTOKINE & GROWTH FACTOR REVIEWS, 2008, 19 (5-6) :371-381

[66]

Proud CG, 2013, BIOCHEM SOC T, V587, P2623

[67] Cross-talk between KLF4 and STAT3 regulates axon regeneration [J].

Qin, Song ;

Zou, Yuhua ;

Zhang, Chun-Li .

NATURE COMMUNICATIONS, 2013, 4

[68] Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation [J].

Qiu, J ;

Cafferty, WBJ ;

McMahon, SB ;

Thompson, SWN .

JOURNAL OF NEUROSCIENCE, 2005, 25 (07) :1645-1653

[69] The hypoxia-induced paralogs scylla and charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila [J].

Reiling, JH ;

Hafen, E .

GENES & DEVELOPMENT, 2004, 18 (23) :2879-2892

[70] The conditioning lesion effect on sympathetic neurite outgrowth is dependent on gp130 cytokines [J].

Sachs, H. Hyatt ;

Rohrer, H. ;

Zigmond, R. E. .

EXPERIMENTAL NEUROLOGY, 2010, 223 (02) :516-522

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