Signaling regulations of neuronal regenerative ability

被引：90

作者：

Lu, Yi ^{[1
,2
,3
]}

Belin, Stephane ^{[2
,3
]}

He, Zhigang ^{[2
,3
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurosurg, Boston, MA 02115 USA

[2] Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2014年 / 27卷

关键词：

PROMOTES AXONAL REGENERATION; LEUKEMIA INHIBITORY FACTOR; RETINAL GANGLION-CELLS; LEUCINE-ZIPPER KINASE; INJURED SPINAL-CORD; OPTIC-NERVE; GROWTH CONE; MAMMALIAN TARGET; IN-VIVO; PTEN;

D O I：

10.1016/j.conb.2014.03.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Different from physiological axon growth during development, a major limiting factor for successful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mammalian central nervous system (CNS). Recent studies identified several molecular pathways, including PTEN/mTOR, Jak/STAT, DLK/JNK, providing important probes in investigating the mechanisms by which the regenerative ability is regulated. This review will summarize these recent findings and speculate their implications.

引用

页码：135 / 142

页数：8

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