High-efficiency loading in small mesopores (2-3 nm) forming a matrix type controlled drug delivery nanosystem

被引：8

作者：

Liu, Fang ^{[1
]}

Zhang, Hongwu ^{[2
]}

Cao, Qingyun ^{[3
]}

Xiang, Xianhong ^{[4
]}

Wang, Liqin ^{[4
]}

He, Ting ^{[1
]}

Liu, Wei ^{[1
]}

Fang, Yueping ^{[1
]}

Deng, David Y. B. ^{[2
]}

Zhou, Wuyi ^{[1
]}

机构：

[1] South China Agr Univ, Coll Sci, Inst Biomat, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Res Ctr Translat Med, Guangzhou 510080, Guangdong, Peoples R China

[3] South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Radiol, Guangzhou 510080, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 17期

关键词：

CONTROLLED-RELEASE; SILICA NANOPARTICLES; SYSTEM; MOLECULES; SIZE; PORE;

D O I：

10.1039/c3ra47035k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein a high-efficiency controlled release nanosystem for fluoroquinolone hydrochlorides was established by a characteristic vacuum-recrystal loaded process based on small pore mesoporous MCM-41. The system exhibited great drug loading capacity (62.31%), matrix type sustained-release behavior (5 days) and excellent biocompatibility in vitro.

引用

页码：8918 / 8921

页数：4