High-efficiency loading in small mesopores (2-3 nm) forming a matrix type controlled drug delivery nanosystem

被引：8

作者：

Liu, Fang ^{[1
]}

Zhang, Hongwu ^{[2
]}

Cao, Qingyun ^{[3
]}

Xiang, Xianhong ^{[4
]}

Wang, Liqin ^{[4
]}

He, Ting ^{[1
]}

Liu, Wei ^{[1
]}

Fang, Yueping ^{[1
]}

Deng, David Y. B. ^{[2
]}

Zhou, Wuyi ^{[1
]}

机构：

[1] South China Agr Univ, Coll Sci, Inst Biomat, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Res Ctr Translat Med, Guangzhou 510080, Guangdong, Peoples R China

[3] South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Radiol, Guangzhou 510080, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 17期

关键词：

CONTROLLED-RELEASE; SILICA NANOPARTICLES; SYSTEM; MOLECULES; SIZE; PORE;

D O I：

10.1039/c3ra47035k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein a high-efficiency controlled release nanosystem for fluoroquinolone hydrochlorides was established by a characteristic vacuum-recrystal loaded process based on small pore mesoporous MCM-41. The system exhibited great drug loading capacity (62.31%), matrix type sustained-release behavior (5 days) and excellent biocompatibility in vitro.

引用

页码：8918 / 8921

页数：4

共 20 条

[1] Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium [J].

Cai, Q ;

Luo, ZS ;

Pang, WQ ;

Fan, YW ;

Chen, XH ;

Cui, FZ .

CHEMISTRY OF MATERIALS, 2001, 13 (02) :258-263

[2] Drug Delivery Technologies: The Way Forward in the New Decade [J].

del Valle, Eva M. Martin ;

Galan, Miguel A. ;

Carbonell, Ruben G. .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2009, 48 (05) :2475-2486

[3] Mesoporous silica material TUD-1 as a drug delivery system [J].

Heikkila, T. ;

Salonen, J. ;

Tuura, J. ;

Hamdy, M. S. ;

Mul, G. ;

Kumar, N. ;

Salmi, T. ;

Murzin, D. Yu ;

Laitinen, L. ;

Kaukonen, A. M. ;

Hirvonen, J. ;

Lehto, V. -P. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 331 (01) :133-138

[4] MECHANISM OF SUSTAINED-ACTION MEDICATION - THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES [J].

HIGUCHI, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (12) :1145-&

[5] Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs [J].

Jia, Lejiao ;

Shen, Jingyi ;

Li, Zhenyu ;

Zhang, Dianrui ;

Zhang, Qiang ;

Duan, Cunxian ;

Liu, Guangpu ;

Zheng, Dandan ;

Liu, Yue ;

Tian, Xiaona .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 439 (1-2) :81-91

[6] Facile Synthesis of Monodispersed Mesoporous Silica Nanoparticles with Ultralarge Pores and Their Application in Gene Delivery [J].

Kim, Mi-Hee ;

Na, Hee-Kyung ;

Kim, Young-Kwan ;

Ryoo, Soo-Ryoon ;

Cho, Hae Sung ;

Lee, Kyung Eun ;

Jeon, Hyesung ;

Ryoo, Ryong ;

Min, Dal-Hee .

ACS NANO, 2011, 5 (05) :3568-3576

[7] A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules [J].

Lai, CY ;

Trewyn, BG ;

Jeftinija, DM ;

Jeftinija, K ;

Xu, S ;

Jeftinija, S ;

Lin, VSY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (15) :4451-4459

[8] Synthesis and Controlled Release Properties of Prednisone Intercalated Mg-Al Layered Double Hydroxide Composite [J].

Li, Fusu ;

Jin, Lan ;

Han, Jingbin ;

Wei, Min ;

Li, Congju .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2009, 48 (12) :5590-5597

[9] Delivery Formulations of Ordered and Nonordered Mesoporous Silica: Comparison of Three Drug Loading Methods [J].

Limnell, Tarja ;

Santos, Helder A. ;

Makila, Ermei ;

Heikkila, Teemu ;

Salonen, Jarno ;

Murzin, Dmitry Yu. ;

Kumar, Narendra ;

Laaksonen, Timo ;

Peltonen, Leena ;

Hirvonen, Jouni .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 100 (08) :3294-3306

[10] Iron oxide-loaded hollow mesoporous silica nanocapsules for controlled drug release and hyperthermia [J].

Lu, Feng ;

Popa, Adriana ;

Zhou, Shiwei ;

Zhu, Jun-Jie ;

Samia, Anna Cristina S. .

CHEMICAL COMMUNICATIONS, 2013, 49 (97) :11436-11438

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