Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

被引:58
作者
Arkwright, Peter D. [1 ,2 ,3 ,4 ]
Riley, Philip [2 ,3 ,4 ]
Hughes, Stephen M. [2 ,3 ,4 ]
Alachkar, Hana [5 ]
Wynn, Robert F. [2 ,3 ,4 ]
机构
[1] Univ Manchester, Inst Inflammat & Repair, Manchester, Lancs, England
[2] Royal Manchester Childrens Hosp, Dept Paediat Immunol, Manchester M27 1HA, Lancs, England
[3] Royal Manchester Childrens Hosp, Dept Rheumatol, Manchester M27 1HA, Lancs, England
[4] Royal Manchester Childrens Hosp, Dept Bone Marrow Transplantat, Manchester M27 1HA, Lancs, England
[5] Salford Royal Fdn Trust, Dept Immunol, Manchester, Lancs, England
关键词
COMPLEMENT; MICE;
D O I
10.1016/j.jaci.2013.07.035
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:265 / 267
页数:7
相关论文
共 6 条
[1]   Complement in human diseases: Lessons from complement deficiencies [J].
Botto, Marina ;
Kirschfink, Michael ;
Macor, Paolo ;
Pickering, Matthew C. ;
Wuerzner, Reinhard ;
Tedesco, Francesco .
MOLECULAR IMMUNOLOGY, 2009, 46 (14) :2774-2783
[2]   Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice [J].
Cortes-Hernandez, J ;
Fossati-Jimack, L ;
Petry, F ;
Loos, M ;
Izui, S ;
Walport, MJ ;
Cook, HT ;
Botto, M .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (12) :3713-3722
[3]  
KAUL M, 1995, J IMMUNOL, V155, P5795
[4]   Reconstitution of the complement function in C1q-deficient (C1qa-/-) mice with wild-type bone marrow cells [J].
Petry, F ;
Botto, M ;
Holtappels, R ;
Walport, MJ ;
Loos, M .
JOURNAL OF IMMUNOLOGY, 2001, 167 (07) :4033-4037
[5]   The role of complement in the early immune response to transplantation [J].
Sacks, Steven H. ;
Zhou, Wuding .
NATURE REVIEWS IMMUNOLOGY, 2012, 12 (06) :431-442
[6]  
Vassallo G, 2007, RHEUMATOLOGY, V16, P12