Pridopidine, a selective Sigma-1 receptor (S1R) agonist promotes neuroprotection in ALS models

被引:0
|
作者
Geva, Michal [1 ]
Wang, Shao-Ming [2 ,3 ,5 ]
Wu, Hsiang-En [2 ,4 ]
Ankol, Lior [6 ,7 ]
Ionescu, Ariel [6 ,7 ]
Gradus-Pery, Tal [6 ,7 ]
Gershoni-Emek, Noga [1 ]
Goldberg, Y. Paul [1 ]
Su, Tsung-Ping [2 ]
Perlson, Eran [6 ,7 ]
Hayden, Michael R. [1 ,8 ]
机构
[1] Prilenia Therapeut, Herzliyya, Israel
[2] Natl Inst Drug Abuse, Natl Inst Hlth, Cellular Pathobiol Sect, Integrat Neurosci Res Branch,Intramural Res Progr, Baltimore, MD USA
[3] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
[4] China Med Univ, Neurosci & Brain Dis Ctr, Taichung, Taiwan
[5] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan
[6] Sagol Sch Neurosci, Tel Aviv, Israel
[7] Sackler Sch Med, Tel Aviv, Israel
[8] Univ British Columbia, CMMT, Vancouver, BC, Canada
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
6
引用
收藏
页码:S4 / S5
页数:2
相关论文
共 50 条
  • [21] Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503
    Hirano, Kohga
    Tagashira, Hideaki
    Fukunaga, Kohji
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2014, 134 (06): : 707 - 713
  • [22] Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
    Ionescu, Ariel
    Gradus, Tal
    Altman, Topaz
    Maimon, Roy
    Avraham, Noi Saraf
    Geva, Michal
    Hayden, Michael
    Perlson, Eran
    CELL DEATH & DISEASE, 2019, 10 (3)
  • [23] Loss of the Sigma-1 receptor disrupts pridopidine-induced gene expression
    Dreymann, Jennifer
    Geva, Michal
    Ross, Jermaine
    Cha, Yoonjeong
    Kusko, Rebecca
    Escalante-Chong, Renan
    Zeskind, Ben
    Laifenfeld, Daphna
    Grossman, Iris
    Hayden, Michael
    NEUROLOGY, 2018, 90
  • [24] Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
    Ariel Ionescu
    Tal Gradus
    Topaz Altman
    Roy Maimon
    Noi Saraf Avraham
    Michal Geva
    Michael Hayden
    Eran Perlson
    Cell Death & Disease, 10
  • [25] The activity of selective sigma-1 receptor ligands,in seizure models in vivo
    Vavers, Edijs
    Svalbe, Baiba
    Lauberte, Lasma
    Stonans, Ilmars
    Misane, Ilga
    Dambrova, Maija
    Zvejniece, Liga
    BEHAVIOURAL BRAIN RESEARCH, 2017, 328 : 13 - 18
  • [26] Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease
    Veronica Francardo
    Michal Geva
    Francesco Bez
    Quentin Denis
    Lilach Steiner
    Michael R. Hayden
    M. Angela Cenci
    Neurotherapeutics, 2019, 16 : 465 - 479
  • [27] Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease
    Francardo, Veronica
    Geva, Michal
    Bez, Francesco
    Denis, Quentin
    Steiner, Lilach
    Hayden, Michael R.
    Cenci, M. Angela
    NEUROTHERAPEUTICS, 2019, 16 (02) : 465 - 479
  • [28] The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism (vol 10, 1346, 2019)
    Liu, Xin
    Qu, Chuan
    Shi, Shaobo
    Ye, Tianxin
    Wang, Linglin
    Liu, Steven
    Zhang, Cui
    Liang, Jinjun
    Hu, Dan
    Yang, Bo
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [29] Pridopidine Rescues Multiple Mitochondrial Functions Impaired in Human and Mouse HD Models by Activation of the Sigma-1 Receptor
    Geva, Michal
    Naia, Luana
    Ly, Philip
    Lopes, Carla
    Mota, Sandra I.
    Maranga, Carina
    Hayden, Michael
    Rego, A. Cristina
    NEUROTHERAPEUTICS, 2019, 16 (04) : 1361 - 1361
  • [30] Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer's disease
    Furuse, T.
    Hashimoto, K.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010, 13 : 74 - 74