Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats

被引：2
作者：
Peng Yu-Shuai [1 ]
Liu Li-Jia [1 ]
Zhao Can [1 ]
Yang Xin [1 ]
Liu Chen [1 ]
Wang Ru-Feng [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2015年 / 13卷 / 07期
关键词：
Veratric acid; Pharmacokinetics; Tissue distribution; FLOWERS;
D O I：
10.1016/S1875-5364(15)30048-0
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats. The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5, 5, and 10 mg.kg(-1) were quantified by HPLC. The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg.kg(-1) were also analyzed. The plasma pharmacokinetic parameters at the three doses were as follows: t(1/2), (86.23 +/- 6.83), (72.66 +/- 4.10) and (71.20 +/- 2.90) min; C-0, (11.10 +/- 1.47), (23.67 +/- 1.24) and (39.17 +/- 3.90) mu g.mL(-1); and AUC(0 ->infinity), (1 240.90 +/- 129.14), (2 273.84 +/- 132.47) and (3 516.4 +/- 403.37) min.mu g.mL(-1), respectively. The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver, heart and kidneys.
引用
收藏
页码：535 / 539
页数：5
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