Novel synthetic routes to PNA monomers and PNA-DNA linker molecules

被引:51
作者
Breipohl, G
Will, DW
Peyman, A
Uhlmann, E
机构
[1] Hoechst Marion Roussel D.
关键词
D O I
10.1016/S0040-4020(97)01044-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Novel methods for the preparation of monomethoxytrityl (Mmt) protected aminoethylglycine building blocks and dimethoxytrityl (Dmt) protected hydroxyethylglycine derivatives useful for the synthesis of polyamide nucleic acids (PNAs) and PNA/DNA chimeras are described. The protecting group strategy employed for PNA monomer synthesis produces easily isolable intermediates, minimizes chromatographic purification, and is suitable for large-scale monomer synthesis. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:14671 / 14686
页数:16
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