RNA virus genomics: a world of possibilities

被引：63
作者：
Holmes, Edward C. [1 ,2 ]
机构：
[1] Penn State Univ, Dept Biol, Mueller Lab, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
[2] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 09期
关键词：
INFLUENZA-A VIRUSES; HUMAN-IMMUNODEFICIENCY-VIRUS; DENGUE VIRUS; ADAMANTANE RESISTANCE; H3N2; VIRUSES; PATHOGEN VIRULENCE; UNITED-STATES; EVOLUTION; HIV-1; EPIDEMIC;
D O I：
10.1172/JCI38050
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The increasing availability of complete genome sequences of RNA viruses has the potential to shed new light on fundamental aspects of their biology. Here, I use case studies of 3 RNA viruses to explore the impact of genomic sequence data, with particular emphasis on influenza A virus. Notably, the studies of RNA virus genomics undertaken to date largely focused on issues of evolution and epidemiology, and they have given these disciplines new impetus. However, genomic data have so far made fewer inroads into areas of more direct importance for disease, prevention, and control; thus, harnessing their full potential remains an important goal.
引用
收藏
页码：2488 / 2495
页数：8
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