A polyherbal vaginal pessary with spermicidal and antimicrobial action: evaluation of its safety

被引：11

作者：

Bagga, R. ^{[1
]}

Raghuvanshi, P.

Gopalan, S.

Das, S. K.

Baweja, R.

Suri, S.

Malhotra, D.

Khare, S.

Talwar, G. P.

机构：

[1] Postgrad Inst Med Educ & Res, Dept Obstet & Gynaecol, Chandigarh 160012, India

[2] Talwar Res Fdn, New Delhi 110068, India

[3] Safdarjang Hosp, New Delhi, India

[4] Kamla Nehru Mem Hosp, Allahabad, Uttar Pradesh, India

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 100卷 / 12期

关键词：

polyherbal vaginal pessary; vaginal microbicide; Praneem; India;

D O I：

10.1016/j.trstmh.2006.01.008

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A polyherbal. vaginal. pessary (Praneem) has been formulated that has antimicrobial. properties against genital pathogens in addition to spermicidal. action. Thus, it has dual potential as a barrier method for contraception and for providing protection against some sexually transmitted infections. The present study reports the findings of a multicentre trial. that was conducted to evaluate the safety of this product. Trials were carried out in 23 women in three centres in India: the Postgraduate Institute of Medical Education and Research, Chandigarh; Safdarjang Hospital, New Delhi; and Kamla Nehru Memorial Hospital, Allahabad. Thorough clinical and pelvic examinations were carried out as well as cervical cytology, blood biochemistry and haematology before and after use of the polyherbal pessary intravaginally once daily for 7 consecutive days. No toxicity was observed on clinical. examination or by laboratory investigations. Daily intravaginal use of this pessary for 7 days had no adverse effects on cervical cytology or on metabolic and organ functions. (C) 2006 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：1164 / 1167

页数：4

共 16 条

[1]

[Anonymous], 1992, NEEM TREE SOLV GLOB

[2]

BANG RA, 1989, LANCET, V1, P85

[3]

BHUJWALA RA, 1985, INDIAN J MED RES, V81, P251

[4] Inhibition of the growth and development of asexual and sexual stages of drug-sensitive and resistant strains of the human malaria parasite Plasmodium falciparum by Neem (Azadirachta indica) fractions [J].

Dhar, R ;

Zhang, K ;

Talwar, GP ;

Garg, S ;

Kumar, N .

JOURNAL OF ETHNOPHARMACOLOGY, 1998, 61 (01) :31-39

[5] STUDIES ON THE CONTRACEPTIVE EFFICACY OF PRANEEM POLYHERBAL CREAM [J].

GARG, S ;

TALUJA, V ;

UPADHYAY, SN ;

TALWAR, GP .

CONTRACEPTION, 1993, 48 (06) :591-596

[6]

Gerbase AC, 1998, SEX TRANSM INFECT, V74, pS12

[7] Phase I safety study of Praneem polyherbal vaginal tablet use among HIV-uninfected women in Pune, India [J].

Joshi, SN ;

Katti, U ;

Godbole, S ;

Bharucha, K ;

Kumar, K ;

Kulkarni, S ;

Risbud, A ;

Mehendale, S .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2005, 99 (10) :769-774

[8]

LADIPO OA, 1994, BARRIER CONTRACEPTIV, P277

[9]

PATEL RP, 1962, INDIAN J MED RES, V57, P302

[10]

Raghuvanshi P, 2001, INDIAN J MED RES, V113, P135

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