Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites

被引：15

作者：

Liu, Yang ^{[1
,2
,3
]}

Zhou, Jizeng ^{[4
]}

Lan, Ting ^{[1
,5
]}

Zhou, Xiaoqing ^{[2
]}

Yang, Yang ^{[4
]}

Li, Chuan ^{[2
]}

Zhang, Quanjun ^{[1
,6
,7
]}

Chen, Min ^{[2
]}

Wei, Shu ^{[8
]}

Zheng, Shuwen ^{[2
]}

Cheng, Lingyin ^{[2
]}

Zheng, Yuling ^{[2
]}

Lai, Liangxue ^{[1
,2
,6
,7
]}

Zou, Qingjian ^{[2
]}

机构：

[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Hong Kong Stem Cell & Regenerat Med Res, CAS Key Lab Regenerat Biol,Joint Res Lab Stem Cel, Guangzhou, Peoples R China

[2] Wuyi Univ, Sch Biotechnol & Hlth Sci, Guangdong Prov Key Lab Large Anim Models Biomed, Jiangmen, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei, Peoples R China

[4] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Peoples R China

[5] Univ Chinese Acad Sci, Beijing, Peoples R China

[6] Bioland Lab Guangzhou Regenerat Med & Hlth Guangd, Guangzhou, Peoples R China

[7] Chinese Acad Med Sci 2019RU015, Res Unit Generat Large Anim Dis Models, Guangzhou, Peoples R China

[8] Yunnan Univ, Sch Life Sci, State Key Lab Conservat & Utilizat Bio Resources, Kunming, Yunnan, Peoples R China

来源：

CELL DISCOVERY | 2022年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

GENOMIC DNA;

D O I：

10.1038/s41421-022-00384-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页数：5

共 10 条

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