Fatal Whipple's disease with severe mental manifestations on relapse - case report and brief advances update

被引：0

作者：

Saraci, George ^{[1
]}

Zaharie, Toader ^{[2
]}

Zaharie, Gabriela Corina ^{[3
]}

Vesa, Stefan Cristian ^{[4
]}

Visovan, Irina Ioana ^{[5
]}

Gheban, Dan ^{[6
]}

Pobirci, Liliana Oana ^{[7
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca, Romania

[2] Reg Inst Gastroenterol & Hepatol, Dept Pathol, Cluj Napoca, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Neonatol, Cluj Napoca, Romania

[4] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmacol Toxicol & Clin Pharmacol, Cluj Napoca, Romania

[5] Med Ctr Gastroenterol Hepatol & Digest Endoscopy, Dept Gastroenterol, Cluj Napoca, Romania

[6] Iuliu Hatieganu Univ Med & Pharm, Dept Pathol, 8 Victor Babes St, Cluj Napoca 40000, Romania

[7] Univ Oradea, Fac Med & Pharm, Dept Neurosci & Rehabil, Oradea, Romania

来源：

ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY | 2019年 / 60卷 / 01期

关键词：

Whipple's disease; Tropheryma whipplei; malabsorption; central nervous system relapse; psychosis; immunopathology; TROPHERYMA-WHIPPLEI; WHIPPELII; RARE;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present the case of a 51-year-old male admitted for asthenia, fatigability, nausea, inappetence, weight loss, watery diarrhea, lower limb paresthesia and diagnosed after further investigations with Whipple's disease (WD). The evolution was favorable under antibiotic therapy but after a period of time the patient was no longer compliant to the treatment and psychotic manifestations, general status alteration and finally the decease occurred. WD is a condition caused by Tropheryma whipplei (TW) bacterium in people with altered macrophage degrading capacity and it is lethal without early treatment.

引用

页码：319 / 323

页数：5

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