Synthesis, Herbicidal Activity, and Molecular Docking of New Pyrazole Ketone Derivatives Containing Flexible Chain

被引：0
作者：
Fu, Qing [1 ,2 ]
Guo, Chang-Fei [1 ,2 ]
Zhong, Liang-Kun [1 ,2 ]
Chen, Jie [3 ]
Tan, Cheng-Xia [1 ]
Weng, Jian-Quan [1 ]
Xu, Tian-Ming [2 ]
Liu, Xing-Hai [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Dept Chem Technol, Hangzhou 310014, Peoples R China
[2] Zhejiang Res Inst Chem Ind, Zhejiang Base Natl Southern Pesticide Res Ctr, Hangzhou 310023, Peoples R China
[3] Zhejiang A&F Univ, Sch Forestry & Biotechnol, Dept Bot, Hangzhou 311300, Peoples R China
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 30卷 / 03期
关键词：
Synthesis; Pyrazole ketone derivatives; 4-Hydoxyphenylpyruvate dioxygenase herbicides; Docking; Herbicidal activity; NEMATOCIDAL ACTIVITY; FUNGICIDAL ACTIVITY; CRYSTAL-STRUCTURE; CARBONATE DERIVATIVES; BIOLOGICAL-ACTIVITY; DESIGN; TRIKETONE; INHIBITORS; SAR;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of pyrazole derivatives was designed, synthesized, and characterized using prodrug theory. Compared with the commercial drug mesotrione, most of title compounds exhibited low herbicidal activity at 150 g/ha. The docking results showed that the binding mode of the key intermediate is the same as the reported inhibitor DAS689.
引用
收藏
页码：361 / 367
页数：7
相关论文
共 50 条
[21]   Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-carboxamide Derivatives Against Meloidogyne incognita [J].
Cheng, Long ;
Zhao, Wen ;
Shen, Zhong-Hua ;
Xu, Tian-Ming ;
Wu, Hong-Ke ;
Peng, Wei-Li ;
Liu, Xing-Hai .
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 16 (01) :29-35
[22]   Synthesis, Characterization, Nematocidal Activity and Docking Study of Novel Pyrazole-4-carboxamide Derivatives [J].
Zhao Wen ;
Shen Zhong-Hua ;
Xing Jia-Hua ;
Xu Tian-Ming ;
Peng Wei-Li ;
Liu Xing-Hai .
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2017, 36 (03) :423-428
[23]   Synthesis, Crystal Structure, Antifungal Activity, and Docking Study of Difluoromethyl Pyrazole Derivatives [J].
Qiao, Li ;
Zhai, Zhi-Wen ;
Cai, Peng-Peng ;
Tan, Cheng-Xia ;
Weng, Jian-Quan ;
Han, Liang ;
Liu, Xing-Hai ;
Zhang, Yong-Gang .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (09) :2536-2541
[24]   Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives [J].
Huczynski, Adam ;
Majcher, Urszula ;
Maj, Ewa ;
Wietrzyk, Joanna ;
Janczak, Jan ;
Moshari, Mahshad ;
Tuszynski, Jack A. ;
Bartl, Franz .
BIOORGANIC CHEMISTRY, 2016, 64 :103-112
[25]   Synthesis, nematicidal activity and docking study of novel chromone derivatives containing substituted pyrazole [J].
Li, Wei ;
Li, Jiuhui ;
Shen, Hongfeng ;
Cheng, Jiagao ;
Li, Zhong ;
Xu, Xiaoyong .
CHINESE CHEMICAL LETTERS, 2018, 29 (06) :911-914
[26]   Synthesis, Antimicrobial Activity, and Molecular Docking of Phenylcarbamate Derivatives Containing a Heterocyclic Fragment [J].
Velikorodov, A. V. ;
Borisova, S. V. ;
Shustova, E. A. ;
Kutlalieva, E. N. .
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2025, 61 (04) :625-634
[27]   Synthesis and Insecticidal Activities of Novel Pyrazole Amide Derivatives Containing a Thiazole Unit [J].
Liang, Kai ;
Zhou, Qian ;
Xun, Xiao ;
Ni, Yadan ;
Li, Jinfeng ;
Shi, Yujun ;
Zhou, Huanyu ;
Wu, Xinxing ;
Shi, Jian ;
Gao, Lei ;
Dai, Hong .
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (06) :1665-1672
[28]   Synthesis, Crystal Structure and Herbicidal Activity of Novel Sulfonylureas Containing Triazolinone Moiety [J].
Pan, Li ;
Chen, Youwei ;
Liu, Zhuo ;
Li, Yonghong ;
Li, Zhengming .
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2013, 33 (03) :542-550
[29]   Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety [J].
Shi, Yujun ;
Li, Yang ;
Fang, Yuan ;
Ye, Linyu ;
Chen, Jia ;
Dai, Hong .
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 36 (06) :1431-1437
[30]   Synthesis and biological activity of acyl thiourea containing difluoromethyl pyrazole motif [J].
Min, Li-Jing ;
Zhai, Zhi-Wen ;
Shi, Yan-Xia ;
Han, Liang ;
Tan, Cheng-Xia ;
Weng, Jian-Quan ;
Li, Bao-Ju ;
Zhang, Yong-Gang ;
Liu, Xing-Hai .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2020, 195 (01) :22-28
12345