Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization

被引:91
作者
Rogers, KV
Dunn, CK
Hebert, SC
Brown, EM
机构
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,RENAL DIV,BOSTON,MA 02115
[2] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,ENDOCRINE DIV,BOSTON,MA 02115
[3] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,HYPERTENS DIV,BOSTON,MA 02115
关键词
calcium; calcium receptor; calcium sensing receptor; parathyroid; G protein coupled receptor; receptor localization; subfornical organ; fluid homeostasis; ion homeostasis;
D O I
10.1016/S0006-8993(96)01070-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The capacity to sense changes in the concentrations of extracellular ions is an important function in several cell types. For example, hormone secretion by parathyroid cells and thyroid C-cells is primarily regulated by the level of extracellular ionized calcium (Ca2+). The G-protein-coupled receptor that mediates the parathyroid cell response to Ca2+ has been cloned and we have used in situ hybridization to map calcium receptor (CaR) mRNA expression in the adult rat brain. Cells expressing CaR mRNA were present in many areas of the brain suggesting that a variety of cell types express the CaR. Particularly high numbers of CaR expressing cells were found in regions associated with the regulation of fluid and mineral homeostasis, most notably the subfomical organ. These data suggest that the capacity to detect changes in extracellular Ca2+ concentrations may have important functional consequences in several neural systems.
引用
收藏
页码:47 / 56
页数:10
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