Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
被引:465
作者:
Nelson, Celeste M.
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机构:Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Nelson, Celeste M.
VanDuijn, Martijn M.
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机构:Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
VanDuijn, Martijn M.
Inman, Jamie L.
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机构:Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Inman, Jamie L.
Fletcher, Daniel A.
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机构:Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Fletcher, Daniel A.
Bissell, Mina J.
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Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Bissell, Mina J.
[1
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机构:
[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA
[3] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
The treelike structures of many organs, including the mammary gland, are generated by branching morphogenesis, a reiterative process of branch initiation and invasion from a preexisting epithelium. Using a micropatterning approach to control the initial three-dimensional structure of mouse mammary epithelial tubules in culture, combined with an algorithm to quantify the extent of branching, we found that the geometry of tubules dictates the position of branches. We predicted numerically and confirm experimentally that branches initiate at sites with a local minimum in the concentration of autocrine inhibitory morphogens, such as transforming growth factor - beta. These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis.
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Bush, KT
Sakurai, H
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Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Sakurai, H
Steer, DL
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Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Steer, DL
Leonard, MO
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机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Leonard, MO
Sampogna, RV
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机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Sampogna, RV
Meyer, TN
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机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Meyer, TN
Schwesinger, C
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Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Schwesinger, C
Qiao, JZ
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机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Qiao, JZ
Nigam, SK
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Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
机构:
Univ Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USAUniv Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USA
Daniel, CW
Smith, GH
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机构:
Univ Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USAUniv Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USA
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Bush, KT
Sakurai, H
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Sakurai, H
Steer, DL
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h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Steer, DL
Leonard, MO
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Leonard, MO
Sampogna, RV
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Sampogna, RV
Meyer, TN
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h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Meyer, TN
Schwesinger, C
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Schwesinger, C
Qiao, JZ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
Qiao, JZ
Nigam, SK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Dept Med Pediat & Cellular Mol Med, La Jolla, CA 92093 USA
机构:
Univ Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USAUniv Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USA
Daniel, CW
Smith, GH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USAUniv Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95060 USA