Cilia, mitochondria, and cardiac development

被引：6

作者：

Chaudhry, Bill ^{[1
]}

Henderson, Deborah J. ^{[1
]}

机构：

[1] Newcastle Univ, Cardiovasc Res Ctr, Inst Med Genet, Cent Pkwy, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 07期

关键词：

D O I：

10.1172/JCI129827

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Motile cilia provide propulsion, and immotile ones are enriched with receptors. Both are required to establish left-right identity in the developing embryo and are also implicated in a wide range of human diseases. Abnormalities in cilial function underlie heterotaxy congenital heart disease (CHD) occurring in individuals with laterality disturbance. Mitochondrial function and cellular energetics, through mTOR and autophagy, are now linked with cilial function, revealing new mechanisms and candidate genes for syndromic human disease. In the current issue of the JCI, Burkhalter et al. ask the question: Can mitochondrial disturbances produce ciliopathy and does this explain some cases of heterotaxy?

引用

页码：2666 / 2668

页数：3

共 20 条

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