From nano to micro to macro: Electrospun hierarchically structured polymeric fibers for biomedical applications

被引：279
作者：
Yang, Guang [1 ,2 ]
Li, Xilin [1 ]
He, Yang [1 ]
Ma, Junkai [1 ]
Ni, Guoli [1 ]
Zhou, Shaobing [1 ]
机构：
[1] Southwest Jiaotong Univ, Minister Educ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
[2] Southwest Jiaotong Univ, Coll Med, Chengdu 610031, Sichuan, Peoples R China
来源：
PROGRESS IN POLYMER SCIENCE | 2018年 / 81卷
基金：
中国国家自然科学基金;
关键词：
Hierarchical structures; Biomaterials; Drug delivery; Tissue engineering; Electrospinning; Three-dimension; FUNCTIONAL COMPOSITE NANOFIBERS; NORMAL HUMAN KERATINOCYTES; DRUG-RELEASE; POLY(VINYL ALCOHOL); FIBROUS MEMBRANES; VASCULAR GRAFTS; SURFACE-MORPHOLOGY; SILK FIBROIN; POLY(EPSILON-CAPROLACTONE) NANOFIBERS; POTENTIAL APPLICATION;
D O I：
10.1016/j.progpolymsci.2017.12.003
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Hierarchically structured polymer fibers encompassing 1-D, 2-D, and 3-D structures with at least one dimension nano- to micro-meters in size have recently received an increasing amount of attention due to their vast potential in such applications as sensing, medicine, energy storage. This review summarizes advancements in the last ten years in the design and fabrication of hierarchically structured polymer fibers via electrospinning technologies, including a diversity of electrospinning devices and electrospinning parameters using various polymers. These well-defined, multilevel structures enable the fibers to be used more effectively in applications in the biomedical field, such as drug delivery, tissue engineering, and diagnostics. This review can provide a better understanding of the relationships between the structure and functionality of polymer fibers for further biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：80 / 113
页数：34
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