Development and Validation of RP-HPLC Method for Estimation of Zolmitriptan in Tablet Dosage Forms

被引：0

作者：

Sankar, D. Gowri ^{[1
]}

Babu, A. Nagesh ^{[1
]}

Rajeswari, A. ^{[1
]}

Krishna, M. Vamsi ^{[1
]}

机构：

[1] Andhra Univ, Univ Coll Pharmaceut Sci, Dept Pharmaceut Anal & Qual Assurance, Visakhapatnam 530003, Andhra Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 07期

关键词：

Zolmitriptan; RP-HPLC; Tablets;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid, simple and precise reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the estimation of zolmitriptan in tablets. The quantification was carried out using a X-Terra RP C-18 column (150 mm x 4.6 mm i.d., 5 mu m particle size) in isocratic mode with mobile phase comprising of phosphate buffer, acetonitrile and methanol in the ratio of 65:15:20 (v/v) at a flow rate of 1 mL/min. The eluent was monitored at 225 nm. The retention time of the drug was 4.278 min. The calibration curve was linear in the concentration range of 5-70 mu g/mL and per cent recovery ranged from 99.8-100.08.

引用

页码：5019 / 5022

页数：4

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