Synthesis, crystal structure, and urease inhibition of an end-on azido-bridged dinuclear copper(II) complex with an oxidized tridentate Schiff base ligand

被引：12
作者：
Wang, Jiaqi [1 ]
Luo, Yingying [1 ]
Zhang, Yixuan [1 ]
Chen, Yue [1 ]
Gao, Fei [1 ]
Ma, Yue [1 ]
Xian, Dongmei [1 ]
You, Zhonglu [1 ]
机构：
[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2021年 / 74卷 / 4-6期
关键词：
Schiff base; copper complex; crystal structure; α -C activation; urease inhibition; JACK-BEAN UREASE; DNA-BINDING; NICKEL(II);
D O I：
10.1080/00958972.2020.1861603
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An end-on azido-bridged dinuclear copper(II) complex, [Cu2L2(mu(1,1)-N-3)(2)], where L is the deprotonated form of N-(2-hydroxy-4-methoxybenzylidene)picolinamide (HL), has been prepared by the reaction of 5-methoxy-2-[(pyridin-2-ylmethylimino)methyl]phenol (HL ') with copper bromide and sodium azide in methanol. The structure of the complex was characterized by elemental analysis, IR and UV-vis spectra, and single crystal X-ray diffraction. The complex possesses crystallographic inversion symmetry, with the two Cu ions (3.36 angstrom) bridged by two end-on azido bridges. Each Cu ion is in a square pyramidal coordination. The original ligand HL ' was unexpectedly oxidized to HL under mild conditions during preparation of the complex. The complex has excellent urease inhibitory activity.
引用
收藏
页码：1028 / 1038
页数：11
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