Inverse Effect of Mucinous Component on Survival in Stage III Colorectal Cancer

被引：14

作者：

Ooki, Akira ^{[1
]}

Akagi, Kiwamu ^{[2
]}

Yatsuoka, Toshimasa ^{[3
]}

Asayama, Masako ^{[1
]}

Hara, Hiroki ^{[1
]}

Yamamoto, Gou ^{[2
]}

Nishimura, Yoji ^{[3
]}

Yamaguchi, Kensei ^{[1
]}

机构：

[1] Saitama Canc Ctr, Dept Gastroenterol, Ina, Saitama 3620806, Japan

[2] Saitama Canc Ctr, Div Mol Diag & Canc Prevent, Ina, Saitama 3620806, Japan

[3] Saitama Canc Ctr, Dept Surg Gastroenterol, Ina, Saitama 3620806, Japan

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2014年 / 110卷 / 07期

关键词：

mucinous adenocarcinoma; mucinous component; colorectal cancer; stage III; COLON-CANCER; ADJUVANT TREATMENT; FLUOROURACIL; LEUCOVORIN; CARCINOMA; HISTOLOGY; OUTCOMES; ADENOCARCINOMA; OXALIPLATIN; PROGRESSION;

D O I：

10.1002/jso.23742

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundAlthough mucinous adenocarcinoma (MAC) is has been recognized as a separate entity in colorectal cancer (CRC), adenocarcinoma with a mucinous component (ACM) remains poorly understood. MethodsThe association of MAC and ACM with disease-free survival (DFS) and overall survival (OS) was examined using the Cox proportional hazard model in 425 consecutive stage III CRCs. ResultsCompared with conventional adenocarcinoma (CAC), patients with MAC exhibited independently worse DFS (hazard ratio [HR], 2.64; 95% CI, 1.21-5.80; P=0.014) and OS (HR, 3.56; 95% CI, 1.53-8.30; P=0.003). Unexpectedly, ACM was significantly associated with worse OS than CAC (P=0.002), despite having a similar DFS to CAC. Further, ACM patients after recurrence exhibited significantly worse OS than CAC patients (P<0.001), similar to MAC. ConclusionsAlthough ACM is similar to CAC with regard to estimated risk of recurrence, the outcome is extremely poor once recurrence occurs and is identical to MAC; one of the most aggressive phenotypes of stage III CRC. Thus, both MAC and ACM are adverse prognostic factors for OS. J. Surg. Oncol. 2014 110:851-857. (c) 2014 Wiley Periodicals, Inc.

引用

页码：851 / 857

页数：7

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