Toxicity of Nerium oleander leaf extract in mice.

被引:0
作者
Haeba, MH [1 ]
Mohamed, AI [1 ]
Mehdi, AWR [1 ]
Nair, GA [1 ]
机构
[1] Univ Garyounis, Fac Sci, Dept Zool, Benghazi, Libya
关键词
body weight gain; electrocardiogram; haematology; mice; nerium oleander; non-lethal and lethal dose;
D O I
暂无
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Non-lethal dose of 701 ethanol extract of the Nerium oleander dry leaves (1000 mg/kg body weight) was subcutaneously injected into male and female mice once a week for 9 weeks (total 10 doses). One day after the last injection, final body weight gain (relative percentage to the initial body weight) had a tendency, in both males and females, towards depression suggesting a metabolic insult at other sites than those involved in myocardial function. Multiple exposure of the mice to the specified dose failed to express a significant influence on blood parameters (WBC RBC, Hb, HCT, PLT) as well as an myocardium. On,the offer hand, a lethal dose (4000 mg/kg body weight) was capable of inducing progressive changes in myocardial electrical activity ending up in cardiac arrest. The electrocardiogram abnormalities could be brought about by the expected Na+, E+-ATPase inhibition by the cardiac glycosides (cardenolides) content of the lethal dose.
引用
收藏
页码:231 / 237
页数:7
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