How transforming growth factor contributes to atrial fibrillation?

被引：15

作者：

Babapoor-Farrokhran, Savalan ^{[1
]}

Rasekhi, Roozbeh Tarighati ^{[2
]}

Gill, Deanna ^{[3
]}

Alzubi, Jafar ^{[1
]}

Mainigi, Sumeet K. ^{[1
,4
]}

机构：

[1] Einstein Med Ctr, Dept Med, Div Cardiol, 5501 Old York Rd, Philadelphia, PA 19141 USA

[2] Emory Univ, Dept Radiol & Imaging Sci, Sch Med, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Med, Sch Med, Atlanta, GA 30322 USA

[4] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA

来源：

LIFE SCIENCES | 2021年 / 266卷

关键词：

Atrial fibrillation; Transforming growth factor-beta; Electrical remodeling; Structural remodeling; Fibrosis; TO-MESENCHYMAL TRANSITION; FACTOR-BETA; CARDIAC FIBROSIS; CATHETER ABLATION; VENTRICULAR FIBROSIS; EXTRACELLULAR-MATRIX; THERAPEUTIC TARGET; ANGIOTENSIN-II; GROWTH-FACTOR-BETA-1; TGF-BETA-1;

D O I：

10.1016/j.lfs.2020.118823

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Atrial fibrillation (AF) is the most common clinically significant arrhythmia. There are four fundamental pathophysiological mechanisms of AF including: electrical remodeling, structural remodeling, autonomic nervous system changes, and Ca2+ handling abnormalities. The transforming growth factor-beta (TGF-beta) superfamily are cytokines that have the ability to regulate numerous cell functions including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix. During the last decade numerous studies have demonstrated that TGF-beta affects the architecture of the heart. TGF-beta 1 has been shown to be involved in the development and propagation of atrial fibrillation (AF). Investigators have studied TGF-beta signaling in AF with the aim of discovering potential therapeutic agents. In this review we discuss the role of TGF-beta in atrial fibrillation and specifically its role in atrial structural and electrical remodeling.

引用

页数：5

共 75 条

[1] The role of long noncoding RNAs in atrial fibrillation [J].

Babapoor-Farrokhran, Savalan ;

Gill, Deanna ;

Rasekhi, Roozbeh Tarighati .

HEART RHYTHM, 2020, 17 (06) :1043-1049

[2] Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration [J].

Bakin, AV ;

Tomlinson, AK ;

Bhowmick, NA ;

Moses, HL ;

Arteaga, CL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :36803-36810

[3] Atrial fibrosis: Mechanisms and clinical relevance in atrial fibrillation [J].

Burstein, Brett ;

Nattel, Stanley .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (08) :802-809

[4] A Prospective DE-MRI Study Evaluating the Role of TGF-β1 in Left Atrial Fibrosis and Implications for Outcomes of Cryoballoon-Based Catheter Ablation: New Insights into Primary Fibrotic Atriocardiomyopathy [J].

Canpolat, Ugur ;

Oto, Ali ;

Hazirolan, Tuncay ;

Sunman, Hamza ;

Yorgun, Hikmet ;

Sahiner, Levent ;

Kaya, Ergun Baris ;

Aytemir, Kudret .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2015, 26 (03) :251-259

[5] LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation [J].

Cao, Feng ;

Li, Zhe ;

Ding, Wen-mao ;

Yan, Ling ;

Zhao, Qing-yan .

MOLECULAR MEDICINE, 2019, 25 (1)

[6] Transforming growth factor-β1 and diabetic nephropathy [J].

Chang, Albert S. ;

Hathaway, Catherine K. ;

Smithies, Oliver ;

Kakoki, Masao .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2016, 310 (08) :F689-F696

[7] Transforming growth factor-β-mediated CD44/STAT3 signaling contributes to the development of atrial fibrosis and fibrillation [J].

Chang, Shang-Hung ;

Yeh, Yung-Hsin ;

Lee, Jia-Lin ;

Hsu, Yu-Juei ;

Kuo, Chi-Tai ;

Chen, Wei-Jan .

BASIC RESEARCH IN CARDIOLOGY, 2017, 112 (05)

[8] MFGE8 attenuates Ang-Il-induced atrial fibrosis and vulnerability to atrial fibrillation through inhibition of TGF-β1/Smad2/3 pathway [J].

Ge, Zhuowang ;

Chen, Youming ;

Wang, Bo ;

Zhang, Xuan ;

Yan, Yexiang ;

Zhou, Lei ;

Zhang, Yachen ;

Xie, Yuquan .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2020, 139 :164-175

[9] TGF-β Signaling in Control of Cardiovascular Function [J].

Goumans, Marie-Jose ;

ten Dijke, Peter .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2018, 10 (02)

[10] Transforming Growth Factor β-Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis? [J].

Goumans, Marie-Jose ;

van Zonneveld, Anton Jan ;

ten Dijke, Peter .

TRENDS IN CARDIOVASCULAR MEDICINE, 2008, 18 (08) :293-298

← 1 2 3 4 5 6 7 8 →