Adverse effects of antiretroviral therapy on liver hepatocytes and endothelium in HIV patients: An ultrastructural perspective

被引：22

作者：

Chwiki, Sarah ^{[1
]}

Campos, Maria Mercedes ^{[1
]}

McLaughlin, Mary E. ^{[2
]}

Kleiner, David E. ^{[3
]}

Kovacs, Joseph A. ^{[4
]}

Morse, Caryn G. ^{[4
]}

Abu-Asab, Mones S. ^{[1
]}

机构：

[1] NEI, Sect Histopathol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NIAID, Lab Immunoregulat, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] NCI, Pathol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA

[4] NIH, Crit Care Med Dept, AIDS Sect, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

来源：

ULTRASTRUCTURAL PATHOLOGY | 2017年 / 41卷 / 02期

关键词：

Antiretroviral therapy; endothelium; hepatotoxicity; HIV; liver; mitochondria; sinusoid; steatosis; HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION; DISEASE; MITOCHONDRIAL; CELLS; MECHANISMS; NEVIRAPINE; EXPOSURE; TYPE-1; ADULTS;

D O I：

10.1080/01913123.2017.1282066

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

Human immunodeficiency virus and antiretroviral therapy (ART) together can be far more detrimental to liver cells than either of the two unaided. However, ultrastructural aspects of the synergistic effects of HIV and ART have been understudied. In a patient cohort receiving ART, this study characterizes ultrastructurally sinusoidal degeneration, hepatocytic aberrations, mitochondrial dysfunction, accumulation of bulky lipid droplets (steatosis), and occlusion of sinusoidal lumina. Mitochondrial dysfunction causes the accumulation of acetyl-CoA which leads to insulin upregulation and resistance, lipid synthesis, and steatosis. Lipid droplets deposited in the sinusoids could be the source of the blood's lipid profile alterations in HIV patients on ART.

引用

页码：186 / 195

页数：10

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