Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2

被引:38
作者
Hollmig, S. Tyler
Ariizumi, Kiyoshi
Cruz, Ponciano D., Jr. [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Dermatol, Dallas, TX 75390 USA
基金
美国国家卫生研究院;
关键词
TOLL-LIKE RECEPTORS; HUMAN DENDRITIC CELLS; BETA-GLUCAN RECEPTOR; INNATE IMMUNE-RESPONSE; SURFACTANT PROTEIN-A; CANDIDA-ALBICANS; DC-SIGN; LANGERHANS CELLS; MANNOSE RECEPTOR; CARBOHYDRATE-RECOGNITION;
D O I
10.1093/glycob/cwp032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The discovery of several transmembrane receptors expressed by antigen presenting cells, including those that detect and interact with specific sugar moieties on the surface of microbes, has improved our understanding of how immunity against infection is generated. This knowledge, in turn, prompted us to review such interactions with emphasis on C-type lectin receptors and a focus on the roles of dectin-1 and dectin-2 in anti-fungal immunity.
引用
收藏
页码:568 / 575
页数:8
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